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10.1016/j.jcrc.2020.07.003

http://scihub22266oqcxt.onion/10.1016/j.jcrc.2020.07.003
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32736197!7340593!32736197
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suck abstract from ncbi


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pmid32736197      J+Crit+Care 2020 ; 60 (ä): 32-37
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  • The characteristics and outcomes of 681 severe cases with COVID-19 in China #MMPMID32736197
  • Chen FF; Zhong M; Liu Y; Zhang Y; Zhang K; Su DZ; Meng X; Zhang Y
  • J Crit Care 2020[Dec]; 60 (ä): 32-37 PMID32736197show ga
  • PURPOSE: To clarify the epidemiological, clinical, and therapeutic features of patients with severe COVID-19. METHODS: In this study, we enrolled 681 patients with confirmed cases of severe COVID-19. The epidemiological, demographic, clinical, laboratory, treatment, and outcome data were collected. RESULTS: The median age of the study participants was 65 years, 53.2% were male, and 104 (15.3%) died. Age, Neutrophil-To-Lymphocyte Ratio (NLR), acute myocardial injury, and levels of C-reactive protein (CRP), lactate dehydrogenase (LDH), and CD3 T cells counts were independently associated with death, while arbidol and ribavirin were protective from death. The combination of NLR and acute myocardial injury on admission (AUC = 0.914) predicted mortality better than NLR, CRP, LDH, and acute myocardial injury. There were 312 (45.8%) patients with cardiovascular disease, of whom 23.4% died. beta-blockers, ACEI/ARB, arbidol, and ribavirin might have a beneficial effect for severe COVID-19 patients with cardiovascular disease. CONCLUSION: The combination of NLR and acute myocardial injury on admission was highly predictive of mortality and survival. Clinicians should adopt more aggressive strategies for patients with a high NLR (>6.66) combined with myocardial injury. beta-blockers and ACEI/ARB, as well as arbidol and ribavirin, were effective in COVID-19 patients with cardiovascular disease.
  • |*COVID-19 Drug Treatment[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Angiotensin Receptor Antagonists/*therapeutic use[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors/*therapeutic use[MESH]
  • |Area Under Curve[MESH]
  • |C-Reactive Protein/metabolism[MESH]
  • |CD3 Complex/metabolism[MESH]
  • |China[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Indoles/therapeutic use[MESH]
  • |L-Lactate Dehydrogenase/metabolism[MESH]
  • |Lymphocyte Count[MESH]
  • |Lymphocytes/cytology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Multivariate Analysis[MESH]
  • |Neutrophils/cytology[MESH]
  • |ROC Curve[MESH]
  • |Retrospective Studies[MESH]
  • |Ribavirin/therapeutic use[MESH]


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