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10.1016/j.antiviral.2020.104874 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2020.104874 32735900!7386308!32735900     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2020 ; 182 (ä): 104874 Nephropedia Template TP {{tp|p=32735900|t=2020. Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses |pdf=|usr=}}{{32735900}} gab.com Text Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=32735900 #FOAvip Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-beta (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target. Twit Text FOAVip Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=32735900 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32735900 #FOAvip English Wikipedia <ref>{{Cite pmid|32735900}}</ref> Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses #MMPMID32735900 Prasanth KR; Hirano M; Fagg WS; McAnarney ET; Shan C; Xie X; Hage A; Pietzsch CA; Bukreyev A; Rajsbaum R; Shi PY; Bedford MT; Bradrick SS; Menachery V; Garcia-Blanco MA Antiviral Res 2020[Oct]; 182 (ä): 104874 PMID32735900show ga Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-beta (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target. |Betacoronavirus/*physiology[MESH] |Cell Line[MESH] |DNA Topoisomerases, Type I/*metabolism[MESH] |Dengue Virus/physiology[MESH] |Ebolavirus/physiology[MESH] |Gene Knockout Techniques[MESH] |Humans[MESH] |Influenza A virus/physiology[MESH] |RNA Viruses/*metabolism[MESH] |SARS-CoV-2[MESH] |Virus Replication/*physiology[MESH] |Yellow fever virus/physiology[MESH]Topoisomerase III-beta is required for efficient replication of positi(epmc).pdf DeepDyve Pubget Overpricing