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10.1007/s15010-020-01468-7

http://scihub22266oqcxt.onion/10.1007/s15010-020-01468-7
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32734556!7391472!32734556
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suck abstract from ncbi


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pmid32734556      Infection 2020 ; 48 (5): 715-722
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  • Prognostic value of serum amyloid A in patients with COVID-19 #MMPMID32734556
  • Cheng L; Yang JZ; Bai WH; Li ZY; Sun LF; Yan JJ; Zhou CL; Tang BP
  • Infection 2020[Oct]; 48 (5): 715-722 PMID32734556show ga
  • OBJECTIVE: To investigate the prognostic value of serum amyloid A (SAA) in the patients with Corona Virus Disease 2019 (COVID-19). METHODS: The medical data of 89 COVID-19 patients admitted to Renmin Hospital of Wuhan University from January 3, 2020 to February 26, 2020 were collected. Eighty-nine cases were divided into survival group (53 cases) and non-survival group (36 cases) according to the results of 28-day follow-up. The SAA levels of all patients were recorded and compared on 1 day after admission (before treatment) and 3 days, 5 days, and 7 days after treatment. The ROC curve was drawn to analyze the prognosis of patients with COVID-19 by SAA. RESULTS: The difference of comparison of SAA between survival group and non-survival group before treatment was not statistically significant, Z(1) = - 1.426, P = 0.154. The Z(1) values (Z(1) is the Z value of the rank sum test) of the two groups of patients at 3 days, 5 days, and 7 days after treatment were - 5.569, - 6.967, and - 7.542, respectively. The P values were all less than 0.001, and the difference was statistically significant. The ROC curve results showed that SAA has higher sensitivity to the prognostic value of 1 day (before treatment), 3 days, 5 days, and 7 days after treatment, with values of 0.806, 0.972, 0.861, and 0.961, respectively. Compared with SAA on the 7th day and C-reactive protein, leukocyte count, neutrophil count, lymphocyte count, and hemoglobin on the 7th day, the sensitivities were: 96.1%, 83.3%, 88.3%, 83.3%, 67.9%, and 83.0%, respectively, of which SAA has the highest sensitivity. CONCLUSION: SAA can be used as a predictor of the prognosis in patients with COVID-19.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus/*pathogenicity[MESH]
  • |Biomarkers/blood[MESH]
  • |C-Reactive Protein/metabolism[MESH]
  • |COVID-19[MESH]
  • |China[MESH]
  • |Coronavirus Infections/blood/*diagnosis/mortality/physiopathology[MESH]
  • |Cough/blood/*diagnosis/mortality/physiopathology[MESH]
  • |Female[MESH]
  • |Fever/blood/*diagnosis/mortality/physiopathology[MESH]
  • |Hemoglobins/metabolism[MESH]
  • |Humans[MESH]
  • |Leukocyte Count[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pharyngitis/blood/*diagnosis/mortality/physiopathology[MESH]
  • |Pneumonia, Viral/blood/*diagnosis/mortality/physiopathology[MESH]
  • |Prognosis[MESH]
  • |ROC Curve[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Serum Amyloid A Protein/*metabolism[MESH]
  • |Severity of Illness Index[MESH]


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