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10.3389/fcell.2020.00549 http://scihub22266oqcxt.onion/10.3389/fcell.2020.00549 32733880!7360683!32733880     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Cell+Dev+Biol 2020 ; 8 (ä): 549 Nephropedia Template TP {{tp|p=32733880|t=2020. TRPM7/RPSA Complex Regulates Pancreatic Cancer Cell Migration |pdf=|usr=}}{{32733880}} gab.com Text TRPM7/RPSA Complex Regulates Pancreatic Cancer Cell Migration JO: Front Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=32733880 #FOAvip Pancreatic ductal adenocarcinoma (PDAC) is a malignancy with a very poor prognosis due to highly metastatic profile. Cell migration is an essential step of the metastatic cascade allowing cancer cells to spread toward target tissues. Recent studies strongly suggest that bioactive elastin peptides, also named elastokines or elastin-derived peptides (EDPs), are released in the extracellular microenvironment during tumoral remodeling of the stroma. EDPs stimulate cancer cell migration by interacting with their membrane receptor, ribosomal protein SA (RPSA). Others membrane proteins like ion channels are also involved in cancer cell migration. It has been recently shown that the transient receptor potential melastatin-related 7 (TRPM7) channel regulates PDAC cell migration and invasion. The objective of this work was to study the effect of EDPs on TRPM7 channel in human pancreatic cancer cells. We showed that EDPs promote MIA PaCa-2 cell migration using Boyden chamber assay. Cells transfected with a siRNA targeting TRPM7 were not able to migrate in response to EDPs indicating that TRPM7 regulated cell migration induced by these peptides. Moreover, EDPs were able to stimulate TRPM7 currents recorded by Patch-Clamp. Finally, we showed that TRPM7 channels and RPSA receptors are colocalized at the plasma membrane of human pancreatic cancer cells. Taken together, our data suggest that TRPM7/RPSA complex regulated human pancreatic cancer cell migration. This complex may be a promising therapeutic target in PDAC. Twit Text FOAVip TRPM7/RPSA Complex Regulates Pancreatic Cancer Cell Migration ????Front Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=32733880 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32733880 #FOAvip English Wikipedia <ref>{{Cite pmid|32733880}}</ref> TRPM7/RPSA Complex Regulates Pancreatic Cancer Cell Migration #MMPMID32733880 Lefebvre T; Rybarczyk P; Bretaudeau C; Vanlaeys A; Cousin R; Brassart-Pasco S; Chatelain D; Dhennin-Duthille I; Ouadid-Ahidouch H; Brassart B; Gautier M Front Cell Dev Biol 2020[]; 8 (ä): 549 PMID32733880show ga Pancreatic ductal adenocarcinoma (PDAC) is a malignancy with a very poor prognosis due to highly metastatic profile. Cell migration is an essential step of the metastatic cascade allowing cancer cells to spread toward target tissues. Recent studies strongly suggest that bioactive elastin peptides, also named elastokines or elastin-derived peptides (EDPs), are released in the extracellular microenvironment during tumoral remodeling of the stroma. EDPs stimulate cancer cell migration by interacting with their membrane receptor, ribosomal protein SA (RPSA). Others membrane proteins like ion channels are also involved in cancer cell migration. It has been recently shown that the transient receptor potential melastatin-related 7 (TRPM7) channel regulates PDAC cell migration and invasion. The objective of this work was to study the effect of EDPs on TRPM7 channel in human pancreatic cancer cells. We showed that EDPs promote MIA PaCa-2 cell migration using Boyden chamber assay. Cells transfected with a siRNA targeting TRPM7 were not able to migrate in response to EDPs indicating that TRPM7 regulated cell migration induced by these peptides. Moreover, EDPs were able to stimulate TRPM7 currents recorded by Patch-Clamp. Finally, we showed that TRPM7 channels and RPSA receptors are colocalized at the plasma membrane of human pancreatic cancer cells. Taken together, our data suggest that TRPM7/RPSA complex regulated human pancreatic cancer cell migration. This complex may be a promising therapeutic target in PDAC. äTRPM7/RPSA Complex Regulates Pancreatic Cancer Cell Migration (epmc).pdf DeepDyve Pubget Overpricing