Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3389/fimmu.2020.01450 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01450 32733480!7363932!32733480     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 1450 Nephropedia Template TP {{tp|p=32733480|t=2020. Viral Evasion of the Complement System and Its Importance for Vaccines and Therapeutics |pdf=|usr=}}{{32733480}} gab.com Text Viral Evasion of the Complement System and Its Importance for Vaccines and Therapeutics JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32733480 #FOAvip The complement system is a key component of innate immunity which readily responds to invading microorganisms. Activation of the complement system typically occurs via three main pathways and can induce various antimicrobial effects, including: neutralization of pathogens, regulation of inflammatory responses, promotion of chemotaxis, and enhancement of the adaptive immune response. These can be vital host responses to protect against acute, chronic, and recurrent viral infections. Consequently, many viruses (including dengue virus, West Nile virus and Nipah virus) have evolved mechanisms for evasion or dysregulation of the complement system to enhance viral infectivity and even exacerbate disease symptoms. The complement system has multifaceted roles in both innate and adaptive immunity, with both intracellular and extracellular functions, that can be relevant to all stages of viral infection. A better understanding of this virus-host interplay and its contribution to pathogenesis has previously led to: the identification of genetic factors which influence viral infection and disease outcome, the development of novel antivirals, and the production of safer, more effective vaccines. This review will discuss the antiviral effects of the complement system against numerous viruses, the mechanisms employed by these viruses to then evade or manipulate this system, and how these interactions have informed vaccine/therapeutic development. Where relevant, conflicting findings and current research gaps are highlighted to aid future developments in virology and immunology, with potential applications to the current COVID-19 pandemic. Twit Text FOAVip Viral Evasion of the Complement System and Its Importance for Vaccines and Therapeutics ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32733480 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32733480 #FOAvip English Wikipedia <ref>{{Cite pmid|32733480}}</ref> Viral Evasion of the Complement System and Its Importance for Vaccines and Therapeutics #MMPMID32733480 Mellors J; Tipton T; Longet S; Carroll M Front Immunol 2020[]; 11 (ä): 1450 PMID32733480show ga The complement system is a key component of innate immunity which readily responds to invading microorganisms. Activation of the complement system typically occurs via three main pathways and can induce various antimicrobial effects, including: neutralization of pathogens, regulation of inflammatory responses, promotion of chemotaxis, and enhancement of the adaptive immune response. These can be vital host responses to protect against acute, chronic, and recurrent viral infections. Consequently, many viruses (including dengue virus, West Nile virus and Nipah virus) have evolved mechanisms for evasion or dysregulation of the complement system to enhance viral infectivity and even exacerbate disease symptoms. The complement system has multifaceted roles in both innate and adaptive immunity, with both intracellular and extracellular functions, that can be relevant to all stages of viral infection. A better understanding of this virus-host interplay and its contribution to pathogenesis has previously led to: the identification of genetic factors which influence viral infection and disease outcome, the development of novel antivirals, and the production of safer, more effective vaccines. This review will discuss the antiviral effects of the complement system against numerous viruses, the mechanisms employed by these viruses to then evade or manipulate this system, and how these interactions have informed vaccine/therapeutic development. Where relevant, conflicting findings and current research gaps are highlighted to aid future developments in virology and immunology, with potential applications to the current COVID-19 pandemic. |*Immune Evasion[MESH] |Animals[MESH] |Antiviral Agents/pharmacology/therapeutic use[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Complement Activation/drug effects[MESH] |Complement Membrane Attack Complex/*immunology[MESH] |Coronavirus Infections/drug therapy/*immunology/*prevention & control/virology[MESH] |Flavivirus Infections/immunology/virology[MESH] |Flavivirus/immunology[MESH] |Humans[MESH] |Pandemics/*prevention & control[MESH] |Pneumonia, Viral/drug therapy/*immunology/*prevention & control/virology[MESH] |SARS-CoV-2[MESH] |Viral Vaccines/*immunology[MESH]Viral Evasion of the Complement System and Its Importance for Vaccines(epmc).pdf DeepDyve Pubget Overpricing