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10.1136/annrheumdis-2020-217712

http://scihub22266oqcxt.onion/10.1136/annrheumdis-2020-217712
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suck abstract from ncbi


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pmid32732245      Ann+Rheum+Dis 2020 ; 79 (10): 1286-1289
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  • Association between treatment with colchicine and improved survival in a single-centre cohort of adult hospitalised patients with COVID-19 pneumonia and acute respiratory distress syndrome #MMPMID32732245
  • Scarsi M; Piantoni S; Colombo E; Airo P; Richini D; Miclini M; Bertasi V; Bianchi M; Bottone D; Civelli P; Cotelli MS; Damiolini E; Galbassini G; Gatta D; Ghirardelli ML; Magri R; Malamani P; Mendeni M; Molinari S; Morotti A; Salada L; Turla M; Vender A; Tincani A; Brucato A; Franceschini F; Furloni R; Andreoli L
  • Ann Rheum Dis 2020[Oct]; 79 (10): 1286-1289 PMID32732245show ga
  • OBJECTIVES: The outbreak of COVID-19 posed the issue of urgently identifying treatment strategies. Colchicine was considered for this purpose based on well-recognised anti-inflammatory effects and potential antiviral properties. In the present study, colchicine was proposed to patients with COVID-19, and its effects compared with 'standard-of-care' (SoC). METHODS: In the public hospital of Esine, northern Italy, 140 consecutive inpatients, with virologically and radiographically confirmed COVID-19 admitted in the period 5-19 March 2020, were treated with 'SoC' (hydroxychloroquine and/or intravenous dexamethasone; and/or lopinavir/ritonavir). They were compared with 122 consecutive inpatients, admitted between 19 March and 5 April 2020, treated with colchicine (1 mg/day) and SoC (antiviral drugs were stopped before colchicine, due to potential interaction). RESULTS: Patients treated with colchicine had a better survival rate as compared with SoC at 21 days of follow-up (84.2% (SE=3.3%) vs 63.6% (SE=4.1%), p=0.001). Cox proportional hazards regression survival analysis showed that a lower risk of death was independently associated with colchicine treatment (HR=0.151 (95% CI 0.062 to 0.368), p<0.0001), whereas older age, worse PaO2/FiO2, and higher serum levels of ferritin at entry were associated with a higher risk. CONCLUSION: This proof-of-concept study may support the rationale of use of colchicine for the treatment of COVID-19. Efficacy and safety must be determined in controlled clinical trials.
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Anti-Inflammatory Agents/*therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Case-Control Studies[MESH]
  • |Cohort Studies[MESH]
  • |Colchicine/*therapeutic use[MESH]
  • |Coronavirus Infections/complications/*drug therapy/mortality[MESH]
  • |Dexamethasone/therapeutic use[MESH]
  • |Drug Combinations[MESH]
  • |Enzyme Inhibitors/therapeutic use[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Italy[MESH]
  • |Lopinavir/therapeutic use[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/*drug therapy/mortality[MESH]
  • |Proof of Concept Study[MESH]
  • |Proportional Hazards Models[MESH]
  • |Respiratory Distress Syndrome/*drug therapy/etiology/mortality[MESH]
  • |Ritonavir/therapeutic use[MESH]
  • |SARS-CoV-2[MESH]


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