Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.3390/ijms21155345

http://scihub22266oqcxt.onion/10.3390/ijms21155345
suck pdf from google scholar
32731360!7432802!32731360
unlimited free pdf from europmc32731360    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi

pmid32731360      Int+J+Mol+Sci 2020 ; 21 (15): ä
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • The Roles of GRKs in Hemostasis and Thrombosis #MMPMID32731360
  • Chen X; Zhao X; Cooper M; Ma P
  • Int J Mol Sci 2020[Jul]; 21 (15): ä PMID32731360show ga
  • Along with cancer, cardiovascular and cerebrovascular diseases remain by far the most common causes of death. Heart attacks and strokes are diseases in which platelets play a role, through activation on ruptured plaques and subsequent thrombus formation. Most platelet agonists activate platelets via G protein-coupled receptors (GPCRs), which make these receptors ideal targets for many antiplatelet drugs. However, little is known about the mechanisms that provide feedback regulation on GPCRs to limit platelet activation. Emerging evidence from our group and others strongly suggests that GPCR kinases (GRKs) are critical negative regulators during platelet activation and thrombus formation. In this review, we will summarize recent findings on the role of GRKs in platelet biology and how one specific GRK, GRK6, regulates the hemostatic response to vascular injury. Furthermore, we will discuss the potential role of GRKs in thrombotic disorders, such as thrombotic events in COVID-19 patients. Studies on the function of GRKs during platelet activation and thrombus formation have just recently begun, and a better understanding of the role of GRKs in hemostasis and thrombosis will provide a fruitful avenue for understanding the hemostatic response to injury. It may also lead to new therapeutic options for the treatment of thrombotic and cardiovascular disorders.
  • |Blood Platelets/metabolism[MESH]
  • |G-Protein-Coupled Receptor Kinases/*metabolism[MESH]
  • |Humans[MESH]
  • |Platelet Activation[MESH]
  • |Receptors, G-Protein-Coupled/*metabolism[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box