Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41586-020-2608-y http://scihub22266oqcxt.onion/10.1038/s41586-020-2608-y 32731258!8436420!32731258     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2020 ; 586 (7830): 578-582 Nephropedia Template TP {{tp|p=32731258|t=2020. ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques |pdf=|usr=}}{{32731258}} gab.com Text ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=32731258 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019(1,2) and is responsible for the coronavirus disease 2019 (COVID-19) pandemic(3). Vaccines are an essential countermeasure and are urgently needed to control the pandemic(4). Here we show that the adenovirus-vector-based vaccine ChAdOx1 nCoV-19, which encodes the spike protein of SARS-CoV-2, is immunogenic in mice and elicites a robust humoral and cell-mediated response. This response was predominantly mediated by type-1 T helper cells, as demonstrated by the profiling of the IgG subclass and the expression of cytokines. Vaccination with ChAdOx1 nCoV-19 (using either a prime-only or a prime-boost regimen) induced a balanced humoral and cellular immune response of type-1 and type-2 T helper cells in rhesus macaques. We observed a significantly reduced viral load in the bronchoalveolar lavage fluid and lower respiratory tract tissue of vaccinated rhesus macaques that were challenged with SARS-CoV-2 compared with control animals, and no pneumonia was observed in vaccinated SARS-CoV-2-infected animals. However, there was no difference in nasal shedding between vaccinated and control SARS-CoV-2-infected macaques. Notably, we found no evidence of immune-enhanced disease after viral challenge in vaccinated SARS-CoV-2-infected animals. The safety, immunogenicity and efficacy profiles of ChAdOx1 nCoV-19 against symptomatic PCR-positive COVID-19 disease will now be assessed in randomized controlled clinical trials in humans. Twit Text FOAVip ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=32731258 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32731258 #FOAvip English Wikipedia <ref>{{Cite pmid|32731258}}</ref> ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques #MMPMID32731258 van Doremalen N; Lambe T; Spencer A; Belij-Rammerstorfer S; Purushotham JN; Port JR; Avanzato VA; Bushmaker T; Flaxman A; Ulaszewska M; Feldmann F; Allen ER; Sharpe H; Schulz J; Holbrook M; Okumura A; Meade-White K; Perez-Perez L; Edwards NJ; Wright D; Bissett C; Gilbride C; Williamson BN; Rosenke R; Long D; Ishwarbhai A; Kailath R; Rose L; Morris S; Powers C; Lovaglio J; Hanley PW; Scott D; Saturday G; de Wit E; Gilbert SC; Munster VJ Nature 2020[Oct]; 586 (7830): 578-582 PMID32731258show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019(1,2) and is responsible for the coronavirus disease 2019 (COVID-19) pandemic(3). Vaccines are an essential countermeasure and are urgently needed to control the pandemic(4). Here we show that the adenovirus-vector-based vaccine ChAdOx1 nCoV-19, which encodes the spike protein of SARS-CoV-2, is immunogenic in mice and elicites a robust humoral and cell-mediated response. This response was predominantly mediated by type-1 T helper cells, as demonstrated by the profiling of the IgG subclass and the expression of cytokines. Vaccination with ChAdOx1 nCoV-19 (using either a prime-only or a prime-boost regimen) induced a balanced humoral and cellular immune response of type-1 and type-2 T helper cells in rhesus macaques. We observed a significantly reduced viral load in the bronchoalveolar lavage fluid and lower respiratory tract tissue of vaccinated rhesus macaques that were challenged with SARS-CoV-2 compared with control animals, and no pneumonia was observed in vaccinated SARS-CoV-2-infected animals. However, there was no difference in nasal shedding between vaccinated and control SARS-CoV-2-infected macaques. Notably, we found no evidence of immune-enhanced disease after viral challenge in vaccinated SARS-CoV-2-infected animals. The safety, immunogenicity and efficacy profiles of ChAdOx1 nCoV-19 against symptomatic PCR-positive COVID-19 disease will now be assessed in randomized controlled clinical trials in humans. |*Disease Models, Animal[MESH] |*Macaca mulatta/immunology/virology[MESH] |Adenoviridae/genetics[MESH] |Animals[MESH] |Betacoronavirus/*immunology[MESH] |Bronchoalveolar Lavage Fluid[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Coronavirus Infections/genetics/*immunology/*prevention & control/virology[MESH] |Cytokines/immunology[MESH] |Female[MESH] |Immunity, Cellular[MESH] |Immunity, Humoral[MESH] |Immunoglobulin G/immunology[MESH] |Lung/immunology/pathology/virology[MESH] |Male[MESH] |Mice[MESH] |Pandemics/*prevention & control[MESH] |Pneumonia, Viral/immunology/*prevention & control/virology[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/genetics/immunology[MESH] |Th1 Cells/immunology[MESH] |Vaccination[MESH] |Viral Load[MESH]ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaqu(epmc).pdf DeepDyve Pubget Overpricing