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10.1038/s41586-020-2607-z http://scihub22266oqcxt.onion/10.1038/s41586-020-2607-z 32731257!7581548!32731257     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32731257&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2020 ; 586 (7830): 583-588 Nephropedia Template TP {{tp|p=32731257|t=2020. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques |pdf=|usr=}}{{32731257}} gab.com Text Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=32731257 #FOAvip A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic(1-8). For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in non-human primates. Fifty-two rhesus macaques (Macaca mulatta) were immunized with Ad26 vectors that encoded S variants or sham control, and then challenged with SARS-CoV-2 by the intranasal and intratracheal routes(9,10). The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or near-complete protection in bronchoalveolar lavage and nasal swabs after SARS-CoV-2 challenge. Titres of vaccine-elicited neutralizing antibodies correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in non-human primates. The optimal Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.S, is currently being evaluated in clinical trials. Twit Text FOAVip Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=32731257 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32731257 #FOAvip English Wikipedia <ref>{{Cite pmid|32731257}}</ref> Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques #MMPMID32731257 Mercado NB; Zahn R; Wegmann F; Loos C; Chandrashekar A; Yu J; Liu J; Peter L; McMahan K; Tostanoski LH; He X; Martinez DR; Rutten L; Bos R; van Manen D; Vellinga J; Custers J; Langedijk JP; Kwaks T; Bakkers MJG; Zuijdgeest D; Rosendahl Huber SK; Atyeo C; Fischinger S; Burke JS; Feldman J; Hauser BM; Caradonna TM; Bondzie EA; Dagotto G; Gebre MS; Hoffman E; Jacob-Dolan C; Kirilova M; Li Z; Lin Z; Mahrokhian SH; Maxfield LF; Nampanya F; Nityanandam R; Nkolola JP; Patel S; Ventura JD; Verrington K; Wan H; Pessaint L; Van Ry A; Blade K; Strasbaugh A; Cabus M; Brown R; Cook A; Zouantchangadou S; Teow E; Andersen H; Lewis MG; Cai Y; Chen B; Schmidt AG; Reeves RK; Baric RS; Lauffenburger DA; Alter G; Stoffels P; Mammen M; Van Hoof J; Schuitemaker H; Barouch DH Nature 2020[Oct]; 586 (7830): 583-588 PMID32731257show ga A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic(1-8). For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in non-human primates. Fifty-two rhesus macaques (Macaca mulatta) were immunized with Ad26 vectors that encoded S variants or sham control, and then challenged with SARS-CoV-2 by the intranasal and intratracheal routes(9,10). The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or near-complete protection in bronchoalveolar lavage and nasal swabs after SARS-CoV-2 challenge. Titres of vaccine-elicited neutralizing antibodies correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in non-human primates. The optimal Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.S, is currently being evaluated in clinical trials. |*Macaca mulatta/immunology/virology[MESH] |Animals[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Coronavirus Infections/*immunology/*prevention & control[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Immunity, Cellular[MESH] |Immunity, Humoral[MESH] |Male[MESH] |Pandemics/*prevention & control[MESH] |Pneumonia, Viral/*immunology/*prevention & control[MESH] |SARS-CoV-2[MESH] |Vaccination[MESH] |Viral Load[MESH]Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaque(epmc).pdf DeepDyve Pubget Overpricing