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10.3201/eid2612.202308

http://scihub22266oqcxt.onion/10.3201/eid2612.202308
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32730733!7706959!32730733
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suck abstract from ncbi


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pmid32730733      Emerg+Infect+Dis 2020 ; 26 (12): 2961-2965
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  • Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells #MMPMID32730733
  • Lau SKP; Wong ACP; Luk HKH; Li KSM; Fung J; He Z; Cheng FKK; Chan TTY; Chu S; Aw-Yong KL; Lau TCK; Fung KSC; Woo PCY
  • Emerg Infect Dis 2020[Dec]; 26 (12): 2961-2965 PMID32730733show ga
  • Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.
  • |Animals[MESH]
  • |COVID-19[MESH]
  • |Chiroptera/virology[MESH]
  • |Humans[MESH]
  • |Middle East Respiratory Syndrome Coronavirus/genetics/physiology[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2/genetics/*physiology[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/genetics/*physiology[MESH]
  • |Viral Tropism/*genetics[MESH]


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