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10.1172/JCI140970 http://scihub22266oqcxt.onion/10.1172/JCI140970 32730233!7598044!32730233     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2020 ; 130 (11): 5967-5975 Nephropedia Template TP {{tp|p=32730233|t=2020. Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2 |pdf=|usr=}}{{32730233}} gab.com Text Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2 JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=32730233 #FOAvip BACKGROUNDInitial reports from the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic described children as being less susceptible to coronavirus disease 2019 (COVID-19) than adults. Subsequently, a severe and novel pediatric disorder termed multisystem inflammatory syndrome in children (MIS-C) emerged. We report on unique hematologic and immunologic parameters that distinguish between COVID-19 and MIS-C and provide insight into pathophysiology.METHODSWe prospectively enrolled hospitalized patients with evidence of SARS-CoV-2 infection and classified them as having MIS-C or COVID-19. Patients with COVID-19 were classified as having either minimal or severe disease. Cytokine profiles, viral cycle thresholds (Cts), blood smears, and soluble C5b-9 values were analyzed with clinical data.RESULTSTwenty patients were enrolled (9 severe COVID-19, 5 minimal COVID-19, and 6 MIS-C). Five cytokines (IFN-gamma, IL-10, IL-6, IL-8, and TNF-alpha) contributed to the analysis. TNF-alpha and IL-10 discriminated between patients with MIS-C and severe COVID-19. The presence of burr cells on blood smears, as well as Cts, differentiated between patients with severe COVID-19 and those with MIS-C.CONCLUSIONPediatric patients with SARS-CoV-2 are at risk for critical illness with severe COVID-19 and MIS-C. Cytokine profiling and examination of peripheral blood smears may distinguish between patients with MIS-C and those with severe COVID-19.FUNDINGFinancial support for this project was provided by CHOP Frontiers Program Immune Dysregulation Team; National Institute of Allergy and Infectious Diseases; National Cancer Institute; the Leukemia and Lymphoma Society; Cookies for Kids Cancer; Alex's Lemonade Stand Foundation for Childhood Cancer; Children's Oncology Group; Stand UP 2 Cancer; Team Connor; the Kate Amato Foundations; Burroughs Wellcome Fund CAMS; the Clinical Immunology Society; the American Academy of Allergy, Asthma, and Immunology; and the Institute for Translational Medicine and Therapeutics. Twit Text FOAVip Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2 ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=32730233 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32730233 #FOAvip English Wikipedia <ref>{{Cite pmid|32730233}}</ref> Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2 #MMPMID32730233 Diorio C; Henrickson SE; Vella LA; McNerney KO; Chase J; Burudpakdee C; Lee JH; Jasen C; Balamuth F; Barrett DM; Banwell BL; Bernt KM; Blatz AM; Chiotos K; Fisher BT; Fitzgerald JC; Gerber JS; Gollomp K; Gray C; Grupp SA; Harris RM; Kilbaugh TJ; John ARO; Lambert M; Liebling EJ; Paessler ME; Petrosa W; Phillips C; Reilly AF; Romberg ND; Seif A; Sesok-Pizzini DA; Sullivan KE; Vardaro J; Behrens EM; Teachey DT; Bassiri H J Clin Invest 2020[Nov]; 130 (11): 5967-5975 PMID32730233show ga BACKGROUNDInitial reports from the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic described children as being less susceptible to coronavirus disease 2019 (COVID-19) than adults. Subsequently, a severe and novel pediatric disorder termed multisystem inflammatory syndrome in children (MIS-C) emerged. We report on unique hematologic and immunologic parameters that distinguish between COVID-19 and MIS-C and provide insight into pathophysiology.METHODSWe prospectively enrolled hospitalized patients with evidence of SARS-CoV-2 infection and classified them as having MIS-C or COVID-19. Patients with COVID-19 were classified as having either minimal or severe disease. Cytokine profiles, viral cycle thresholds (Cts), blood smears, and soluble C5b-9 values were analyzed with clinical data.RESULTSTwenty patients were enrolled (9 severe COVID-19, 5 minimal COVID-19, and 6 MIS-C). Five cytokines (IFN-gamma, IL-10, IL-6, IL-8, and TNF-alpha) contributed to the analysis. TNF-alpha and IL-10 discriminated between patients with MIS-C and severe COVID-19. The presence of burr cells on blood smears, as well as Cts, differentiated between patients with severe COVID-19 and those with MIS-C.CONCLUSIONPediatric patients with SARS-CoV-2 are at risk for critical illness with severe COVID-19 and MIS-C. Cytokine profiling and examination of peripheral blood smears may distinguish between patients with MIS-C and those with severe COVID-19.FUNDINGFinancial support for this project was provided by CHOP Frontiers Program Immune Dysregulation Team; National Institute of Allergy and Infectious Diseases; National Cancer Institute; the Leukemia and Lymphoma Society; Cookies for Kids Cancer; Alex's Lemonade Stand Foundation for Childhood Cancer; Children's Oncology Group; Stand UP 2 Cancer; Team Connor; the Kate Amato Foundations; Burroughs Wellcome Fund CAMS; the Clinical Immunology Society; the American Academy of Allergy, Asthma, and Immunology; and the Institute for Translational Medicine and Therapeutics. |*Coronavirus Infections/blood/epidemiology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/blood/epidemiology[MESH] |*Systemic Inflammatory Response Syndrome/blood/epidemiology[MESH] |Adolescent[MESH] |Betacoronavirus/*metabolism[MESH] |COVID-19[MESH] |Child[MESH] |Child, Preschool[MESH] |Complement Membrane Attack Complex/*metabolism[MESH] |Cytokines/*blood[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Prospective Studies[MESH] |SARS-CoV-2[MESH]Multisystem inflammatory syndrome in children and COVID-19 are distinc(epmc).pdf DeepDyve Pubget Overpricing