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10.37201/req/072.2020

http://scihub22266oqcxt.onion/10.37201/req/072.2020
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32729288!7528411!32729288
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suck abstract from ncbi


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pmid32729288      Rev+Esp+Quimioter 2020 ; 33 (5): 369-378
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  • The first 100 cases of COVID-19 in a Hospital in Madrid with a 2-month follow-up #MMPMID32729288
  • Munoz P; Galar A; Catalan P; Valerio M; Aldamiz-Echevarria T; Colliga C; Bouza E
  • Rev Esp Quimioter 2020[Oct]; 33 (5): 369-378 PMID32729288show ga
  • OBJECTIVE: There are few descriptions of the clinical presentation and evolution of consecutive SARS-CoV-2 infections with a long-enough follow up. METHODS: Description of the first consecutive 100 patients with microbiologically-proven COVID-19 in a large hospital in Madrid, Spain including a minimum of two-month follow up. RESULTS: The median age of the patients (52% males) was 61.5 years (IQR=39.5-82.0) and the median BMI was 28.8 kg/m2 (IQR=24.7-33.7). Overall 72% of the patients had one or more co-morbid conditions with a median age-adjusted Charlson index of 2 (IQR=0-5.7). Five patients (5%) were immunosuppressed. The most common symptoms at the time of diagnosis were fever (80.0%), cough (53.0%) and dyspnea (23.0%). The median O2 saturation at the time of first examination was 94% (IQR=90-97). Chest X-ray on admission was compatible with pneumonia in 63% of the cases (bilateral in 42% and unilateral in 21%). Overall, 30% were managed at home and 70% were admitted to the hospital. Thirteen patients were admitted to the ICU with a median of 11 days of stay in the Unit (IQR=6.0-28.0). CALL score of our population ranged from 4 to 13. Overall, 60.0% of patients received antibiotic treatment and 66.0%, empirical antiviral treatment, mainly with lopinavir/ritonavir (65%) or hydroxychloroquine (42%). Mortality, with a minimum of 60 days of follow up, was 23%. The median age of the deceased patients was 85 years (IQR=79-93). CONCLUSIONS: We found a high mortality in the first 100 patients diagnosed with COVID-19 at our institution, associated with advanced age and the presence of serious underlying diseases.
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |Age Distribution[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Body Mass Index[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19 Testing[MESH]
  • |Child[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/diagnosis/drug therapy/*epidemiology/mortality[MESH]
  • |Female[MESH]
  • |Fever/etiology[MESH]
  • |Follow-Up Studies[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/drug therapy/*epidemiology/mortality[MESH]
  • |SARS-CoV-2[MESH]
  • |Spain/epidemiology[MESH]
  • |Symptom Assessment[MESH]
  • |Time Factors[MESH]


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