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10.1007/s12012-020-09596-0

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32729064!7387874!32729064
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suck abstract from ncbi


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pmid32729064      Cardiovasc+Toxicol 2020 ; 20 (5): 443-447
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  • COVID-19: A Concern for Cardiovascular Disease Patients #MMPMID32729064
  • Sharma S
  • Cardiovasc Toxicol 2020[Oct]; 20 (5): 443-447 PMID32729064show ga
  • Coronavirus disease 2019 (COVID-19) is declared as a pandemic that has spread worldwide, affecting 205 countries. The disease affected 1, 40, 43, 176 individuals and caused 5, 97, 583 deaths around the globe. The organism responsible for the cause of disease is Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). SARS-CoV-2 enters into the cell via receptors present on the cell surface named angiotensin-converting enzyme 2 (ACE2) receptor. Notwithstanding ACE2 receptors acts as a gateway for infection, and most of the cardiovascular patients are treated with the ACE inhibitors. Thus, the role of ACE inhibitors or angiotensin receptor blockers may play a critical role in the severity or outcome of disease. Also, the effect of ACE inhibitors varies with the polymorphism in ACE2 receptors present in the individuals. Hence, it is the need of the hour to investigate the mechanisms which could better aid in the treatment of COVID-19-infected cardiovascular disease (CVD) patients.
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors/adverse effects/*therapeutic use[MESH]
  • |Betacoronavirus/*pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Cardiovascular Agents/adverse effects/*therapeutic use[MESH]
  • |Cardiovascular Diseases/*drug therapy/enzymology/mortality/physiopathology[MESH]
  • |Coronavirus Infections/enzymology/mortality/*virology[MESH]
  • |Host Microbial Interactions[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Patient Safety[MESH]
  • |Peptidyl-Dipeptidase A/genetics/*metabolism[MESH]
  • |Pharmacogenomic Variants[MESH]
  • |Pneumonia, Viral/enzymology/mortality/*virology[MESH]
  • |Polymorphism, Genetic[MESH]
  • |Prognosis[MESH]
  • |Risk Assessment[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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