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10.1007/s12192-020-01145-6

http://scihub22266oqcxt.onion/10.1007/s12192-020-01145-6
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suck abstract from ncbi


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pmid32729001      Cell+Stress+Chaperones 2020 ; 25 (5): 731-735
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  • SARS-CoV-2 and Guillain-Barre syndrome: molecular mimicry with human heat shock proteins as potential pathogenic mechanism #MMPMID32729001
  • Lucchese G; Floel A
  • Cell Stress Chaperones 2020[Sep]; 25 (5): 731-735 PMID32729001show ga
  • Severe acute respiratory syndrome-related coronavirus 2 infection has been associated with Guillain-Barre syndrome. We investigated here the potential mechanism underlying the virus-induced damage of the peripheral nervous systems by searching the viral amino acid sequence for peptides common to human autoantigens associated with immune-mediated polyneuropathies. Our results show molecular mimicry between the virus and human heat shock proteins 90 and 60, which are associated with Guillain-Barre syndrome and other autoimmune diseases. Crucially, the shared peptides are embedded in immunoreactive epitopes that have been experimentally validated in the human host.
  • |*Chaperonin 60/chemistry/immunology[MESH]
  • |*HSP90 Heat-Shock Proteins/chemistry/immunology[MESH]
  • |*Mitochondrial Proteins/chemistry/immunology[MESH]
  • |*Viral Proteins/chemistry/immunology[MESH]
  • |Amino Acid Sequence[MESH]
  • |Autoantigens[MESH]
  • |Betacoronavirus/*metabolism[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*virology[MESH]
  • |Databases, Protein[MESH]
  • |Guillain-Barre Syndrome/*metabolism[MESH]
  • |Humans[MESH]
  • |Immunodominant Epitopes[MESH]
  • |Molecular Mimicry[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*virology[MESH]


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