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10.1126/sciimmunol.abd5709

http://scihub22266oqcxt.onion/10.1126/sciimmunol.abd5709
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32727884!7594018!32727884
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suck abstract from ncbi


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pmid32727884      Sci+Immunol 2020 ; 5 (49): ä
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  • SARS-CoV-2 seroprevalence among parturient women in Philadelphia #MMPMID32727884
  • Flannery DD; Gouma S; Dhudasia MB; Mukhopadhyay S; Pfeifer MR; Woodford EC; Gerber JS; Arevalo CP; Bolton MJ; Weirick ME; Goodwin EC; Anderson EM; Greenplate AR; Kim J; Han N; Pattekar A; Dougherty J; Kuthuru O; Mathew D; Baxter AE; Vella LA; Weaver J; Verma A; Leite R; Morris JS; Rader DJ; Elovitz MA; Wherry EJ; Puopolo KM; Hensley SE
  • Sci Immunol 2020[Jul]; 5 (49): ä PMID32727884show ga
  • Limited data are available for pregnant women affected by SARS-CoV-2. Serological tests are critically important for determining SARS-CoV-2 exposures within both individuals and populations. We validated a SARS-CoV-2 spike receptor binding domain serological test using 834 pre-pandemic samples and 31 samples from COVID-19 recovered donors. We then completed SARS-CoV-2 serological testing of 1,293 parturient women at two centers in Philadelphia from April 4 to June 3, 2020. We found 80/1,293 (6.2%) of parturient women possessed IgG and/or IgM SARS-CoV-2-specific antibodies. We found race/ethnicity differences in seroprevalence rates, with higher rates in Black/non-Hispanic and Hispanic/Latino women. Of the 72 seropositive women who also received nasopharyngeal polymerase chain reaction testing during pregnancy, 46 (64%) were positive. Continued serologic surveillance among pregnant women may inform perinatal clinical practices and can potentially be used to estimate exposure to SARS-CoV-2 within the community.
  • |*Health Status Disparities[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral/*blood/immunology[MESH]
  • |Betacoronavirus/immunology/*isolation & purification[MESH]
  • |Black or African American/statistics & numerical data[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques/methods/statistics & numerical data[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/blood/diagnosis/*epidemiology/immunology/virology[MESH]
  • |Female[MESH]
  • |Hispanic or Latino/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/blood/immunology[MESH]
  • |Immunoglobulin M/blood/immunology[MESH]
  • |Pandemics[MESH]
  • |Philadelphia/epidemiology[MESH]
  • |Pneumonia, Viral/blood/*epidemiology/immunology/virology[MESH]
  • |Pregnancy[MESH]
  • |Pregnancy Complications, Infectious/blood/*epidemiology/immunology/virology[MESH]
  • |Protein Domains/immunology[MESH]
  • |SARS-CoV-2[MESH]
  • |Seroepidemiologic Studies[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]


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