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10.1186/s12931-020-01465-2 http://scihub22266oqcxt.onion/10.1186/s12931-020-01465-2 32727465!7389162!32727465     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Respir+Res 2020 ; 21 (1): 201 Nephropedia Template TP {{tp|p=32727465|t=2020. Association between cytokine profiles and lung injury in COVID-19 pneumonia |pdf=|usr=}}{{32727465}} gab.com Text Association between cytokine profiles and lung injury in COVID-19 pneumonia JO: Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=32727465 #FOAvip BACKGROUND: Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investigate the association between cytokine profiles and lung injury in COVID-19 pneumonia. METHODS: This retrospective study was conducted in COVID-19 patients. Demographic characteristics, symptoms, signs, underlying diseases, and laboratory data were collected. The patients were divided into COVID-19 with pneumonia and without pneumonia. CT severity score and PaO(2)/FiO(2) ratio were used to assess lung injury. RESULTS: 106 patients with 12 COVID-19 without pneumonia and 94 COVID-19 with pneumonia were included. Compared with COVID-19 without pneumonia, COVID-19 with pneumonia had significantly higher serum interleukin (IL)-2R, IL-6, and tumor necrosis factor (TNF)-alpha. Correlation analysis showed that CT severity score and PaO(2)/FiO(2) were significantly correlated with age, presence of any coexisting disorder, lymphocyte count, procalcitonin, IL-2R, and IL-6. In multivariate analysis, log IL6 was the only independent explanatory variables for CT severity score (beta = 0.397, p < 0.001) and PaO(2)/FiO(2) (beta = - 0.434, p = 0.003). CONCLUSIONS: Elevation of circulating cytokines was significantly associated with presence of pneumonia in COVID-19 and the severity of lung injury in COVID-19 pneumonia. Circulating IL-6 independently predicted the severity of lung injury in COVID-19 pneumonia. Twit Text FOAVip Association between cytokine profiles and lung injury in COVID-19 pneumonia ????Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=32727465 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32727465 #FOAvip English Wikipedia <ref>{{Cite pmid|32727465}}</ref> Association between cytokine profiles and lung injury in COVID-19 pneumonia #MMPMID32727465 Chen LD; Zhang ZY; Wei XJ; Cai YQ; Yao WZ; Wang MH; Huang QF; Zhang XB Respir Res 2020[Jul]; 21 (1): 201 PMID32727465show ga BACKGROUND: Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investigate the association between cytokine profiles and lung injury in COVID-19 pneumonia. METHODS: This retrospective study was conducted in COVID-19 patients. Demographic characteristics, symptoms, signs, underlying diseases, and laboratory data were collected. The patients were divided into COVID-19 with pneumonia and without pneumonia. CT severity score and PaO(2)/FiO(2) ratio were used to assess lung injury. RESULTS: 106 patients with 12 COVID-19 without pneumonia and 94 COVID-19 with pneumonia were included. Compared with COVID-19 without pneumonia, COVID-19 with pneumonia had significantly higher serum interleukin (IL)-2R, IL-6, and tumor necrosis factor (TNF)-alpha. Correlation analysis showed that CT severity score and PaO(2)/FiO(2) were significantly correlated with age, presence of any coexisting disorder, lymphocyte count, procalcitonin, IL-2R, and IL-6. In multivariate analysis, log IL6 was the only independent explanatory variables for CT severity score (beta = 0.397, p < 0.001) and PaO(2)/FiO(2) (beta = - 0.434, p = 0.003). CONCLUSIONS: Elevation of circulating cytokines was significantly associated with presence of pneumonia in COVID-19 and the severity of lung injury in COVID-19 pneumonia. Circulating IL-6 independently predicted the severity of lung injury in COVID-19 pneumonia. |*Betacoronavirus[MESH] |Adult[MESH] |Biomarkers/blood[MESH] |COVID-19[MESH] |Coronavirus Infections/blood/*complications/epidemiology[MESH] |Cytokines/*blood[MESH] |Female[MESH] |Humans[MESH] |Lung Injury/blood/diagnosis/*etiology[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*complications/diagnosis/epidemiology[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]Association between cytokine profiles and lung injury in COVID-19 pneu(epmc).pdf DeepDyve Pubget Overpricing