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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Headache+Pain 2020 ; 21 (1): 94 Nephropedia Template TP
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Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study #MMPMID32727345
Trigo J; Garcia-Azorin D; Planchuelo-Gomez A; Martinez-Pias E; Talavera B; Hernandez-Perez I; Valle-Penacoba G; Simon-Campo P; de Lera M; Chavarria-Miranda A; Lopez-Sanz C; Gutierrez-Sanchez M; Martinez-Velasco E; Pedraza M; Sierra A; Gomez-Vicente B; Arenillas JF; Guerrero AL
J Headache Pain 2020[Jul]; 21 (1): 94 PMID32727345show ga
INTRODUCTION: Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality. METHODS: Retrospective cohort study. We included all consecutive patients admitted to the Hospital with confirmed SARS-CoV-2 infection between March 8th and April 11th, 2020. We collected demographic data, clinical variables and laboratory abnormalities. We used multivariate regression analysis. RESULTS: During the study period, 576 patients were included, aged 67.2 (SD: 14.7), and 250/576 (43.3%) being female. Presence of headache was described by 137 (23.7%) patients. The all-cause in-hospital mortality rate was 127/576 (20.0%). In the multivariate analysis, patients with headache had a lower risk of mortality (OR: 0.39, 95% CI: 0.17-0.88, p = 0.007). After adjusting for multiple comparisons in a multivariate analysis, variables that were independently associated with a higher odds of having headache in COVID-19 patients were anosmia, myalgia, female sex and fever; variables that were associated with a lower odds of having headache were younger age, lower score on modified Rankin scale, and, regarding laboratory variables on admission, increased C-reactive protein, abnormal platelet values, lymphopenia and increased D-dimer. CONCLUSION: Headache is a frequent symptom in COVID-19 patients and its presence is an independent predictor of lower risk of mortality in COVID-19 hospitalized patients.