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10.1513/AnnalsATS.202005-521OC

http://scihub22266oqcxt.onion/10.1513/AnnalsATS.202005-521OC
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32726561!7706604!32726561
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suck abstract from ncbi


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pmid32726561      Ann+Am+Thorac+Soc 2020 ; 17 (12): 1576-1582
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  • A Survey-based Estimate of COVID-19 Incidence and Outcomes among Patients with Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension and Impact on the Process of Care #MMPMID32726561
  • Lee JD; Burger CD; Delossantos GB; Grinnan D; Ralph DD; Rayner SG; Ryan JJ; Safdar Z; Ventetuolo CE; Zamanian RT; Leary PJ
  • Ann Am Thorac Soc 2020[Dec]; 17 (12): 1576-1582 PMID32726561show ga
  • Rationale: Patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) typically undergo frequent clinical evaluation. The incidence and outcomes of coronavirus disease (COVID-19) and its impact on routine management for patients with pulmonary vascular disease is currently unknown.Objectives: To assess the cumulative incidence and outcomes of recognized COVID-19 for patients with PAH/CTEPH followed at accredited pulmonary hypertension centers, and to evaluate the pandemic's impact on clinic operations at these centers.Methods: A survey was e-mailed to program directors of centers accredited by the Pulmonary Hypertension Association. Descriptive analyses and linear regression were used to analyze results.Results: Seventy-seven center directors were successfully e-mailed a survey, and 58 responded (75%). The cumulative incidence of COVID-19 recognized in individuals with PAH/CTEPH was 2.9 cases per 1,000 patients, similar to the general U.S. population. In patients with PAH/CTEPH for whom COVID-19 was recognized, 30% were hospitalized and 12% died. These outcomes appear worse than the general population. A large impact on clinic operations was observed including fewer clinic visits and substantially increased use of telehealth. A majority of centers curtailed diagnostic testing and a minority limited new starts of medical therapy. Most centers did not use experimental therapies in patients with PAH/CTEPH diagnosed with COVID-19.Conclusions: The cumulative incidence of COVID-19 recognized in patients with PAH/CTEPH appears similar to the broader population, although outcomes may be worse. Although the total number of patients with PAH/CTEPH recognized to have COVID-19 was small, the impact of COVID-19 on broader clinic operations, testing, and treatment was substantial.
  • |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH]
  • |Adrenal Cortex Hormones/therapeutic use[MESH]
  • |Alanine/analogs & derivatives/therapeutic use[MESH]
  • |Antibodies, Monoclonal, Humanized/therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Azithromycin/therapeutic use[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |COVID-19/*epidemiology/therapy[MESH]
  • |Cardiac Catheterization/statistics & numerical data[MESH]
  • |Chloroquine/therapeutic use[MESH]
  • |Chronic Disease[MESH]
  • |Computed Tomography Angiography/statistics & numerical data[MESH]
  • |Delivery of Health Care[MESH]
  • |Echocardiography/statistics & numerical data[MESH]
  • |Hospital Mortality[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Hypertension, Pulmonary/diagnosis/epidemiology/etiology/therapy[MESH]
  • |Immunization, Passive[MESH]
  • |Incidence[MESH]
  • |Intensive Care Units[MESH]
  • |Pulmonary Arterial Hypertension/diagnosis/*epidemiology/therapy[MESH]
  • |Pulmonary Embolism/complications/diagnosis/*epidemiology/therapy[MESH]
  • |Surveys and Questionnaires[MESH]
  • |Telemedicine/statistics & numerical data[MESH]


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