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10.1371/journal.pone.0235987 http://scihub22266oqcxt.onion/10.1371/journal.pone.0235987 32726325!7390267!32726325     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2020 ; 15 (7): e0235987 Nephropedia Template TP {{tp|p=32726325|t=2020. Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2 |pdf=|usr=}}{{32726325}} gab.com Text Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2 JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=32726325 #FOAvip Development of novel approaches for regulating the expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) is becoming increasingly important within the context of the ongoing COVID-19 pandemic since these enzymes play a crucial role in cell infection. In this work we searched for putative ACE2 and TMPRSS2 expression regulation networks mediated by various miRNA isoforms (isomiR) across different human organs using publicly available paired miRNA/mRNA-sequencing data from The Cancer Genome Atlas (TCGA) project. As a result, we identified several miRNA families targeting ACE2 and TMPRSS2 genes in multiple tissues. In particular, we found that lysine-specific demethylase 5B (JARID1B), encoded by the KDM5B gene, can indirectly affect ACE2 / TMPRSS2 expression by repressing transcription of hsa-let-7e / hsa-mir-125a and hsa-mir-141 / hsa-miR-200 miRNA families which are targeting these genes. Twit Text FOAVip Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2 ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=32726325 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32726325 #FOAvip English Wikipedia <ref>{{Cite pmid|32726325}}</ref> Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2 #MMPMID32726325 Nersisyan S; Shkurnikov M; Turchinovich A; Knyazev E; Tonevitsky A PLoS One 2020[]; 15 (7): e0235987 PMID32726325show ga Development of novel approaches for regulating the expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) is becoming increasingly important within the context of the ongoing COVID-19 pandemic since these enzymes play a crucial role in cell infection. In this work we searched for putative ACE2 and TMPRSS2 expression regulation networks mediated by various miRNA isoforms (isomiR) across different human organs using publicly available paired miRNA/mRNA-sequencing data from The Cancer Genome Atlas (TCGA) project. As a result, we identified several miRNA families targeting ACE2 and TMPRSS2 genes in multiple tissues. In particular, we found that lysine-specific demethylase 5B (JARID1B), encoded by the KDM5B gene, can indirectly affect ACE2 / TMPRSS2 expression by repressing transcription of hsa-let-7e / hsa-mir-125a and hsa-mir-141 / hsa-miR-200 miRNA families which are targeting these genes. |*Betacoronavirus[MESH] |*Gene Expression Regulation[MESH] |3' Untranslated Regions[MESH] |Angiotensin-Converting Enzyme 2[MESH] |COVID-19[MESH] |Coronavirus Infections/*enzymology/virology[MESH] |Databases, Genetic[MESH] |Gene Regulatory Networks[MESH] |Humans[MESH] |Jumonji Domain-Containing Histone Demethylases/genetics[MESH] |MicroRNAs/*genetics/metabolism[MESH] |Nuclear Proteins/genetics[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*genetics/metabolism[MESH] |Pneumonia, Viral/*enzymology/virology[MESH] |RNA Isoforms/genetics[MESH] |RNA, Messenger/*genetics/metabolism[MESH] |RNA-Seq[MESH] |Repressor Proteins/genetics[MESH] |SARS-CoV-2[MESH] |Serine Endopeptidases/*genetics/metabolism[MESH]Integrative analysis of miRNA and mRNA sequencing data reveals potenti(epmc).pdf DeepDyve Pubget Overpricing