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10.5811/westjem.2020.6.47919

http://scihub22266oqcxt.onion/10.5811/westjem.2020.6.47919
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32726241!7390589!32726241
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suck abstract from ncbi


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pmid32726241      West+J+Emerg+Med 2020 ; 21 (4): 779-784
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  • Predictors of Mortality in Adults Admitted with COVID-19: Retrospective Cohort Study from New York City #MMPMID32726241
  • Chilimuri S; Sun H; Alemam A; Mantri N; Shehi E; Tejada J; Yugay A; Nayudu SK
  • West J Emerg Med 2020[Jul]; 21 (4): 779-784 PMID32726241show ga
  • INTRODUCTION: Rapid spread of coronavirus disease 2019 (COVID-19) in the United States, especially in New York City (NYC), led to a tremendous increase in hospitalizations and mortality. There is very limited data available that associates outcomes during hospitalization in patients with COVID-19. METHODS: In this retrospective cohort study, we reviewed the health records of patients with COVID-19 who were admitted from March 9-April 9, 2020, to a community hospital in NYC. Subjects with confirmed reverse transcriptase-polymerase chain reaction (RT-PCR) of the nasopharyngeal swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) were included. We collected data related to demographics, laboratory results, and outcome of hospitalization. Outcome was measured based on whether the patient was discharged home or died during hospitalization. RESULTS: There were 888 consecutive admissions with COVID-19 during the study period, of which 513 were excluded with pending outcome or incomplete information. We included a total of 375 patients in the study, of whom 215 (57%) survived and 160 (43%) died during hospitalization. The majority of patients were male (63%) and of Hispanic origin (66%) followed by Blacks (25%), and others (9%). Hypertension (60%) stands out to be the most common comorbidity followed by diabetes mellitus (47%), cardiovascular disease (17%), chronic kidney disease (17%), and human immunodeficiency virus/acquired immunodeficiency syndrome (9%). On multiple regression analysis, increasing odds of mortality during hospitalization was associated with older age (odds ratio [OR] 1.04; 95% confidence interval [CI], 1.01-1.06 per year increase; p < 0.0001), admission D-dimer more than 1000 nanograms per milliliter (ng/mL) (OR 3.16; 95% CI, 1.75-5.73; p<0.0001), admission C-reactive protein (CRP) levels of more than 200 milligrams per liter (mg/L) (OR 2.43; 95% CI, 1.36-4.34; p = 0.0028), and admission lymphopenia (OR 2.63; CI, 1.47-4.69; p 0.0010). CONCLUSION: In this retrospective cohort study originating in NYC, older age, admission levels of D-dimer of more than 1000 ng/mL, CRP of more than 200 mg/L and lymphopenia were associated with mortality in individuals hospitalized for COVID-19. We recommend using these risk factors on admission to triage patients to critical care units or surge units to maximize the use of surge capacity beds.
  • |*Betacoronavirus[MESH]
  • |*Hospitalization[MESH]
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19[MESH]
  • |Cardiovascular Diseases/epidemiology[MESH]
  • |Cohort Studies[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/*mortality[MESH]
  • |Diabetes Mellitus/epidemiology[MESH]
  • |Female[MESH]
  • |Fibrin Fibrinogen Degradation Products/analysis[MESH]
  • |HIV Infections/epidemiology[MESH]
  • |Hospitals, Community[MESH]
  • |Humans[MESH]
  • |Hypertension/epidemiology[MESH]
  • |Lymphopenia/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |New York City/epidemiology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*mortality[MESH]
  • |Racial Groups/statistics & numerical data[MESH]
  • |Renal Insufficiency, Chronic/epidemiology[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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