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10.1152/ajpendo.00295.2020 http://scihub22266oqcxt.onion/10.1152/ajpendo.00295.2020 32726128!7473885!32726128     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Endocrinol+Metab 2020 ; 319 (3): E562-E567 Nephropedia Template TP {{tp|p=32726128|t=2020. Sex-derived attributes contributing to SARS-CoV-2 mortality |pdf=|usr=}}{{32726128}} gab.com Text Sex-derived attributes contributing to SARS-CoV-2 mortality JO: Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=32726128 #FOAvip Epidemiological data in COVID-19 mortality indicate that men are more prone to die of SARS-CoV-2 infection than women, but biological causes for this sexual dimorphism are unknown. We discuss the prospective behavioral and biological differences between the sexes that could be attributed to this sex-based differentiation. The female sex hormones and the immune stimulatory genes, including Toll-like receptors, interleukins, and micro-RNAs present on X-chromosome, may impart lesser infectivity and mortality of the SARS-CoV-2 in females over males. The sex hormone estrogen interacts with the renin-angiotensin-aldosterone system, one of the most critical pathways in COVID-19 infectivity, and modulates the vasomotor homeostasis. Testosterone on the contrary enhances the levels of the two most critical molecules, angiotensin-converting enzyme 2 (ACE2) and the transmembrane protease serine-type 2 (TMPRSS2), transcriptionally and posttranslationally, thereby increasing viral load and delaying viral clearance in men as compared with women. We propose that modulating sex hormones, either by increasing estrogen or antiandrogen, may be a therapeutic option to reduce mortality from SARS-CoV-2. Twit Text FOAVip Sex-derived attributes contributing to SARS-CoV-2 mortality ????Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=32726128 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32726128 #FOAvip English Wikipedia <ref>{{Cite pmid|32726128}}</ref> Sex-derived attributes contributing to SARS-CoV-2 mortality #MMPMID32726128 Chanana N; Palmo T; Sharma K; Kumar R; Graham BB; Pasha Q Am J Physiol Endocrinol Metab 2020[Sep]; 319 (3): E562-E567 PMID32726128show ga Epidemiological data in COVID-19 mortality indicate that men are more prone to die of SARS-CoV-2 infection than women, but biological causes for this sexual dimorphism are unknown. We discuss the prospective behavioral and biological differences between the sexes that could be attributed to this sex-based differentiation. The female sex hormones and the immune stimulatory genes, including Toll-like receptors, interleukins, and micro-RNAs present on X-chromosome, may impart lesser infectivity and mortality of the SARS-CoV-2 in females over males. The sex hormone estrogen interacts with the renin-angiotensin-aldosterone system, one of the most critical pathways in COVID-19 infectivity, and modulates the vasomotor homeostasis. Testosterone on the contrary enhances the levels of the two most critical molecules, angiotensin-converting enzyme 2 (ACE2) and the transmembrane protease serine-type 2 (TMPRSS2), transcriptionally and posttranslationally, thereby increasing viral load and delaying viral clearance in men as compared with women. We propose that modulating sex hormones, either by increasing estrogen or antiandrogen, may be a therapeutic option to reduce mortality from SARS-CoV-2. |*Sex Characteristics[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/drug effects/metabolism/*pathogenicity[MESH] |COVID-19[MESH] |Coronavirus Infections/epidemiology/genetics/*mortality/virology[MESH] |Estradiol/metabolism/pharmacology[MESH] |Female[MESH] |Gene Expression Regulation/drug effects[MESH] |Gonadal Steroid Hormones/*physiology[MESH] |Humans[MESH] |Male[MESH] |Mortality[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics/metabolism[MESH] |Pneumonia, Viral/epidemiology/genetics/*mortality/virology[MESH] |Renin-Angiotensin System/drug effects[MESH] |SARS-CoV-2[MESH] |Serine Endopeptidases/genetics/metabolism[MESH] |Sex Factors[MESH]Sex-derived attributes contributing to SARS-CoV-2 mortality (epmc).pdf DeepDyve Pubget Overpricing