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10.19540/j.cnki.cjcmm.20200430.501

http://scihub22266oqcxt.onion/10.19540/j.cnki.cjcmm.20200430.501
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32726003!ä!32726003

suck abstract from ncbi


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pmid32726003      Zhongguo+Zhong+Yao+Za+Zhi 2020 ; 45 (13): 2993-3000
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  • Large- scale prospective clinical study on prophylactic intervention of COVID-19 in community population using Huoxiang Zhengqi Oral Liquid and Jinhao Jiere Granules #MMPMID32726003
  • Yan BH; Jiang ZW; Zeng JP; Tang JY; Ding H; Xia JL; Qin SR; Jin SC; Lu Y; Zhang N; Wang ZH; Li HY; Sang XY; Wu LN; Tang SY; Li Y; Tao MY; Wang QL; Wang JD; Xie HY; Chen QY; Yang SW; Hu NS; Yang JQ; Bao XX; Zhang Q; Yang XL; Jiang CY; Luo HY; Cai ZH; Yu SG
  • Zhongguo Zhong Yao Za Zhi 2020[Jul]; 45 (13): 2993-3000 PMID32726003show ga
  • To scientifically evaluate the intervention effect of Chinese medicine preventive administration(combined use of Huo-xiang Zhengqi Oral Liquid and Jinhao Jiere Granules) on community population in the case of coronavirus disease 2019(COVID-19), a large cohort, prospective, randomized, and parallel-controlled clinical study was conducted. Total 22 065 subjects were included and randomly divided into 2 groups. The non-intervention group was given health guidance only, while the traditional Chinese medicine(TCM) intervention group was given two coordinated TCM in addition to health guidance. The medical instructions were as follows. Huoxiang Zhengqi Oral Liquid: oral before meals, 10 mL/time, 2 times/day, a course of 5 days. Jinhao Jiere Granules: dissolve in boiling water and take after meals, 8 g/time, 2 times/day, a course of 5 days, followed up for 14 days, respectively. The study found that with the intake of medication, the incidence rate of TCM intervention group was basically maintained at a low and continuous stable level(0.01%-0.02%), while the non-intervention group showed an overall trend of continuous growth(0.02%-0.18%) from 3 to 14 days. No suspected or confirmed COVID-19 case occurred in either group. There were 2 cases of colds in the TCM intervention group and 26 cases in the non-intervention group. The incidence of colds in the TCM intervention group was significantly lower(P<0.05) than that in the non-intervention group. In the population of 16-60 years old, the incidence rate of non-intervention and intervention groups were 0.01% and 0.25%, respectively. The difference of colds incidence between the two groups was statistically significant(P<0.05). In the population older than 60 years old, they were 0.04% and 0.21%, respectively. The incidence of colds in the non-intervention group was higher than that in the intervention group, but not reaching statistical difference. The protection rate of TCM for the whole population was 91.8%, especially for the population of age 16-60(95.0%). It was suggested that TCM intervention(combined use of Huoxiang Zhengqi Oral Liquid and Jinhao Jiere Granules) could effectively protect community residents against respiratory diseases, such as colds, which was worthy of promotion in the community. In addition, in terms of safety, the incidence of adverse events and adverse reactions in the TCM intervention group was relatively low, which was basically consistent with the drug instructions.
  • |*Betacoronavirus[MESH]
  • |*Coronavirus Infections/drug therapy[MESH]
  • |*Drugs, Chinese Herbal[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/drug therapy[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Humans[MESH]
  • |Medicine, Chinese Traditional[MESH]
  • |Middle Aged[MESH]
  • |Prospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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