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Pulmonary function in patients surviving to COVID-19 pneumonia #MMPMID32725597
Fumagalli A; Misuraca C; Bianchi A; Borsa N; Limonta S; Maggiolini S; Bonardi DR; Corsonello A; Di Rosa M; Soraci L; Lattanzio F; Colombo D
Infection 2021[Feb]; 49 (1): 153-157 PMID32725597show ga
PURPOSE: The aim of our study was to assess respiratory function at the time of clinical recovery and 6 weeks after discharge in patients surviving to COVID-19 pneumonia. METHODS: Our case series consisted of 13 patients with COVID-19 pneumonia. RESULTS: At the time of clinical recovery, FEV1 (2.07 +/- 0.72 L) and FVC (2.25 +/- 0.86 L) were lower compared to lower limit of normality (LLN) values (2.56 +/- 0.53 L, p = 0.004, and 3.31 +/- 0.65 L, p < 0.001, respectively), while FEV1/FVC (0.94 +/- 0.07) was higher compared to upper limit of normality (ULN) values (0.89 +/- 0.01, p = 0.029). After 6 weeks pulmonary function improved but FVC was still lower than ULN (2.87 +/- 0.81, p = 0.014). CONCLUSION: These findings suggest that COVID-19 pneumonia may result in clinically relevant alterations in pulmonary function tests, with a mainly restrictive pattern.