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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Neural+Transm+(Vienna) 2020 ; 127 (9): 1217-1228 Nephropedia Template TP
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Coronaviruses: a challenge of today and a call for extended human postmortem brain analyses #MMPMID32725545
Riederer P; Ter Meulen V
J Neural Transm (Vienna) 2020[Sep]; 127 (9): 1217-1228 PMID32725545show ga
While there is abounding literature on virus-induced pathology in general and coronavirus in particular, recent evidence accumulates showing distinct and deleterious brain affection. As the respiratory tract connects to the brain without protection of the blood-brain barrier, SARS-CoV-2 might in the early invasive phase attack the cardiorespiratory centres located in the medulla/pons areas, giving rise to disturbances of respiration and cardiac problems. Furthermore, brainstem regions are at risk to lose their functional integrity. Therefore, long-term neurological as well as psychiatric symptomatology and eventual respective disorders cannot be excluded as evidenced from influenza-A triggered post-encephalitic Parkinsonism and HIV-1 triggered AIDS-dementia complex. From the available evidences for coronavirus-induced brain pathology, this review concludes a number of unmet needs for further research strategies like human postmortem brain analyses. SARS-CoV-2 mirroring experimental animal brain studies, characterization of time-dependent and region-dependent spreading behaviours of coronaviruses, enlightening of pathological mechanisms after coronavirus infection using long-term animal models and clinical observations of patients having had COVID-19 infection are calling to develop both protective strategies and drug discoveries to avoid early and late coronavirus-induced functional brain disturbances, symptoms and eventually disorders. To fight SARS-CoV-2, it is an urgent need to enforce clinical, molecular biological, neurochemical and genetic research including brain-related studies on a worldwide harmonized basis.
|*Betacoronavirus[MESH]
|*Diagnosis[MESH]
|Blood-Brain Barrier/pathology/virology[MESH]
|Brain/*pathology/virology[MESH]
|COVID-19[MESH]
|Coronavirus Infections/*pathology[MESH]
|Diagnostic Techniques and Procedures/trends[MESH]