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10.1016/j.conctc.2020.100614

http://scihub22266oqcxt.onion/10.1016/j.conctc.2020.100614
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32724866!7366075!32724866
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suck abstract from ncbi

pmid32724866      Contemp+Clin+Trials+Commun 2020 ; 19 (?): 100614
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  • Pragmatic, adaptive clinical trials: Is 2020 the dawning of a new age? #MMPMID32724866
  • Branch-Elliman W; Lehmann LS; Boden WE; Ferguson R; Monach P
  • Contemp Clin Trials Commun 2020[Sep]; 19 (?): 100614 PMID32724866show ga
  • Given the high case fatality rate of SARS-CoV-2, for which there is no cure and no vaccine, clinicians are forced to make decisions about how best to manage patients with limited high-quality evidence to guide treatment. Traditional randomized controlled trials provide strong experimental evidence, however, tend to be slow, inflexible, and have limited generalizability. Adaptive and pragmatic designs are an attractive alternative, which meet our ethical obligation during the SARS-CoV-2 pandemic to balance speed, agility, and generalizability with both prospective study and scientific rigor.
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