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10.1073/pnas.2006824117

http://scihub22266oqcxt.onion/10.1073/pnas.2006824117
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32723824!7443927!32723824
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suck abstract from ncbi


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pmid32723824      Proc+Natl+Acad+Sci+U+S+A 2020 ; 117 (33): 20198-20201
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  • Haplotype networks of SARS-CoV-2 infections in the Diamond Princess cruise ship outbreak #MMPMID32723824
  • Sekizuka T; Itokawa K; Kageyama T; Saito S; Takayama I; Asanuma H; Nao N; Tanaka R; Hashino M; Takahashi T; Kamiya H; Yamagishi T; Kakimoto K; Suzuki M; Hasegawa H; Wakita T; Kuroda M
  • Proc Natl Acad Sci U S A 2020[Aug]; 117 (33): 20198-20201 PMID32723824show ga
  • The Diamond Princess cruise ship was put under quarantine offshore Yokohama, Japan, after a passenger who disembarked in Hong Kong was confirmed as a coronavirus disease 2019 case. We performed whole-genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly from PCR(+) clinical specimens and conducted a phylogenetic analysis of the outbreak. All tested isolates exhibited a transversion at G(11083)T, suggesting that SARS-CoV-2 dissemination on the Diamond Princess originated from a single introduction event before the quarantine started. Although further spreading might have been prevented by quarantine, some progeny clusters could be linked to transmission through mass-gathering events in the recreational areas and direct transmission among passengers who shared cabins during the quarantine. This study demonstrates the usefulness of haplotype network/phylogeny analysis in identifying potential infection routes.
  • |*Genome, Viral[MESH]
  • |*Haplotypes[MESH]
  • |*Phylogeny[MESH]
  • |*Ships[MESH]
  • |Betacoronavirus/classification/*genetics/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/prevention & control/transmission/*virology[MESH]
  • |Humans[MESH]
  • |Pandemics/prevention & control[MESH]
  • |Pneumonia, Viral/prevention & control/transmission/*virology[MESH]
  • |Quarantine[MESH]
  • |SARS-CoV-2[MESH]


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