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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2020 ; 117 (33): 20198-20201 Nephropedia Template TP
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Haplotype networks of SARS-CoV-2 infections in the Diamond Princess cruise ship outbreak #MMPMID32723824
Proc Natl Acad Sci U S A 2020[Aug]; 117 (33): 20198-20201 PMID32723824show ga
The Diamond Princess cruise ship was put under quarantine offshore Yokohama, Japan, after a passenger who disembarked in Hong Kong was confirmed as a coronavirus disease 2019 case. We performed whole-genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly from PCR(+) clinical specimens and conducted a phylogenetic analysis of the outbreak. All tested isolates exhibited a transversion at G(11083)T, suggesting that SARS-CoV-2 dissemination on the Diamond Princess originated from a single introduction event before the quarantine started. Although further spreading might have been prevented by quarantine, some progeny clusters could be linked to transmission through mass-gathering events in the recreational areas and direct transmission among passengers who shared cabins during the quarantine. This study demonstrates the usefulness of haplotype network/phylogeny analysis in identifying potential infection routes.