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10.1177/0300060520939746 http://scihub22266oqcxt.onion/10.1177/0300060520939746 32722979!7391440!32722979     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Int+Med+Res 2020 ; 48 (7): 300060520939746 Nephropedia Template TP {{tp|p=32722979|t=2020. Endothelial activation and dysfunction in metabolic syndrome, type 2 diabetes and coronavirus disease 2019 |pdf=|usr=}}{{32722979}} gab.com Text Endothelial activation and dysfunction in metabolic syndrome, type 2 diabetes and coronavirus disease 2019 JO: J Int Med Res http://www.kidney.de/pget.php?&tw=1&pmid=32722979 #FOAvip The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 infection is a serious global concern. Increased morbidity and mortality is associated with older age, male gender, cardiovascular disease, diabetes, and smoking. As COVID-19 spreads from coastal borders, both state to state and country to country, our understanding of its pathophysiology has evolved. Age and type 2 diabetes mellitus (T2DM) play especially important roles in COVID-19 progression. T2DM is an age-related disease associated with metabolic syndrome, obesity, insulin resistance (hyperinsulinemia), hyperlipidemia, hypertension, hyperglycemia, and endothelial activation and dysfunction. This review evaluates the relationships and intersection between endothelial cell activation and dysfunction in T2DM and COVID-19. COVID-19 induces multiple injuries of the terminal bronchioles and alveolar blood-gas barrier and associated ultrastructural tissue remodeling. COVID-19 may unmask multiple vulnerabilities associated with T2DM including damage to the endothelial glycocalyx and multiple end-organ macro and microvascular diseases. Unmasking existing vulnerabilities in diabetic patients with COVID-19 is important. Globally, we must come together to better understand why T2DM is associated with increased COVID-19 morbidity and mortality. Twit Text FOAVip Endothelial activation and dysfunction in metabolic syndrome, type 2 diabetes and coronavirus disease 2019 ????J Int Med Res http://www.kidney.de/pget.php?&tw=1&pmid=32722979 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32722979 #FOAvip English Wikipedia <ref>{{Cite pmid|32722979}}</ref> Endothelial activation and dysfunction in metabolic syndrome, type 2 diabetes and coronavirus disease 2019 #MMPMID32722979 Hayden MR J Int Med Res 2020[Jul]; 48 (7): 300060520939746 PMID32722979show ga The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 infection is a serious global concern. Increased morbidity and mortality is associated with older age, male gender, cardiovascular disease, diabetes, and smoking. As COVID-19 spreads from coastal borders, both state to state and country to country, our understanding of its pathophysiology has evolved. Age and type 2 diabetes mellitus (T2DM) play especially important roles in COVID-19 progression. T2DM is an age-related disease associated with metabolic syndrome, obesity, insulin resistance (hyperinsulinemia), hyperlipidemia, hypertension, hyperglycemia, and endothelial activation and dysfunction. This review evaluates the relationships and intersection between endothelial cell activation and dysfunction in T2DM and COVID-19. COVID-19 induces multiple injuries of the terminal bronchioles and alveolar blood-gas barrier and associated ultrastructural tissue remodeling. COVID-19 may unmask multiple vulnerabilities associated with T2DM including damage to the endothelial glycocalyx and multiple end-organ macro and microvascular diseases. Unmasking existing vulnerabilities in diabetic patients with COVID-19 is important. Globally, we must come together to better understand why T2DM is associated with increased COVID-19 morbidity and mortality. |*Betacoronavirus[MESH] |Animals[MESH] |Blood-Air Barrier/pathology/physiopathology[MESH] |Bronchioles/pathology/physiopathology[MESH] |COVID-19[MESH] |Comorbidity[MESH] |Coronavirus Infections/*complications/epidemiology/*physiopathology[MESH] |Diabetes Mellitus, Type 2/*complications/epidemiology/*physiopathology[MESH] |Drug Repositioning[MESH] |Endothelial Cells/pathology/*physiology[MESH] |Humans[MESH] |Metabolic Syndrome/*complications/epidemiology/*physiopathology[MESH] |Models, Biological[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/epidemiology/*physiopathology[MESH] |Pulmonary Alveoli/physiology/physiopathology[MESH] |Rats[MESH] |SARS-CoV-2[MESH]Endothelial activation and dysfunction in metabolic syndrome, type 2 d(epmc).pdf DeepDyve Pubget Overpricing