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10.3390/cells9081777 http://scihub22266oqcxt.onion/10.3390/cells9081777 32722449!7465902!32722449     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2020 ; 9 (8): ä Nephropedia Template TP {{tp|p=32722449|t=2020. A Message from the Human Placenta: Structural and Immunomodulatory Defense against SARS-CoV-2 |pdf=|usr=}}{{32722449}} gab.com Text A Message from the Human Placenta: Structural and Immunomodulatory Defense against SARS-CoV-2 JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=32722449 #FOAvip The outbreak of the coronavirus disease 2019 (COVID-19) pandemic has caused a global public health crisis. Viral infections may predispose pregnant women to a higher rate of pregnancy complications, including preterm births, miscarriage, and stillbirth. Despite reports of neonatal COVID-19, definitive proof of vertical transmission is still lacking. In this review, we summarize studies regarding the potential evidence for transplacental transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), characterize the expression of its receptors and proteases, describe the placental pathology and analyze virus-host interactions at the maternal-fetal interface. We focus on the syncytium, the barrier between mother and fetus, and describe in detail its physical and structural defense against viral infections. We further discuss the potential molecular mechanisms, whereby the placenta serves as a defense front against pathogens by regulating the interferon type III signaling, microRNA-triggered autophagy and the nuclear factor-kappaB pathway. Based on these data, we conclude that vertical transmission may occur but rare, ascribed to the potent physical barrier, the fine-regulated placental immune defense and modulation strategies. Particularly, immunomodulatory mechanisms employed by the placenta may mitigate violent immune response, maybe soften cytokine storm tightly associated with severely ill COVID-19 patients, possibly minimizing cell and tissue damages, and potentially reducing SARS-CoV-2 transmission. Twit Text FOAVip A Message from the Human Placenta: Structural and Immunomodulatory Defense against SARS-CoV-2 ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=32722449 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32722449 #FOAvip English Wikipedia <ref>{{Cite pmid|32722449}}</ref> A Message from the Human Placenta: Structural and Immunomodulatory Defense against SARS-CoV-2 #MMPMID32722449 Kreis NN; Ritter A; Louwen F; Yuan J Cells 2020[Jul]; 9 (8): ä PMID32722449show ga The outbreak of the coronavirus disease 2019 (COVID-19) pandemic has caused a global public health crisis. Viral infections may predispose pregnant women to a higher rate of pregnancy complications, including preterm births, miscarriage, and stillbirth. Despite reports of neonatal COVID-19, definitive proof of vertical transmission is still lacking. In this review, we summarize studies regarding the potential evidence for transplacental transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), characterize the expression of its receptors and proteases, describe the placental pathology and analyze virus-host interactions at the maternal-fetal interface. We focus on the syncytium, the barrier between mother and fetus, and describe in detail its physical and structural defense against viral infections. We further discuss the potential molecular mechanisms, whereby the placenta serves as a defense front against pathogens by regulating the interferon type III signaling, microRNA-triggered autophagy and the nuclear factor-kappaB pathway. Based on these data, we conclude that vertical transmission may occur but rare, ascribed to the potent physical barrier, the fine-regulated placental immune defense and modulation strategies. Particularly, immunomodulatory mechanisms employed by the placenta may mitigate violent immune response, maybe soften cytokine storm tightly associated with severely ill COVID-19 patients, possibly minimizing cell and tissue damages, and potentially reducing SARS-CoV-2 transmission. |*Infectious Disease Transmission, Vertical[MESH] |Autophagy/immunology[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/immunology/*transmission/virology[MESH] |Female[MESH] |Humans[MESH] |Infant, Newborn[MESH] |MicroRNAs/genetics/metabolism[MESH] |Pandemics[MESH] |Placenta/*immunology/metabolism/pathology/*virology[MESH] |Pneumonia, Viral/immunology/*transmission/virology[MESH] |Pregnancy[MESH] |Pregnancy Complications, Infectious/*immunology/virology[MESH]A Message from the Human Placenta: Structural and Immunomodulatory Def(epmc).pdf DeepDyve Pubget Overpricing