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10.3390/jcm9082369

http://scihub22266oqcxt.onion/10.3390/jcm9082369
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32722191!7463984!32722191
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suck abstract from ncbi


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pmid32722191      J+Clin+Med 2020 ; 9 (8): ä
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  • Head-to-Head Accuracy Comparison of Three Commercial COVID-19 IgM/IgG Serology Rapid Tests #MMPMID32722191
  • Andrey DO; Cohen P; Meyer B; Torriani G; Yerly S; Mazza L; Calame A; Arm-Vernez I; Guessous I; Stringhini S; Roux-Lombard P; Fontao L; Agoritsas T; Stirnemann J; Reny JL; Siegrist CA; Eckerle I; Kaiser L; Vuilleumier N
  • J Clin Med 2020[Jul]; 9 (8): ä PMID32722191show ga
  • BACKGROUND: Comparative data of SARS-CoV-2 IgM/IgG serology rapid diagnostic tests (RDTs) is scarce. We thus performed a head-to-head comparison of three RDTs. METHODS: In this unmatched case-control study, blood samples from 41 RT-PCR-confirmed COVID-19 cases and 50 negative controls were studied. The diagnostic accuracy of three commercially available COVID-19 RDTs: NTBIO (RDT-A), Orient-Gene (RDT-B), and MEDsan (RDT-C), against both a recombinant spike-expressing immunofluorescence assay (rIFA) and Euroimmun IgG ELISA, was assessed. RDT results concordant with the reference methods, and between whole blood and plasma, were established by the Kendall coefficient. RESULTS: COVID-19 cases' median time from RT-PCR to serology was 22 days (interquartile range (IQR) 13-31 days). Whole-blood IgG detection with RDT-A, -B, and -C showed 0.93, 0.83, and 0.98 concordance with rIFA. Against rIFA, RDT-A sensitivity (SN) was 92% (95% CI: 78-98) and specificity (SP) 100% (95% CI: 91-100), RDT-B showed 87% SN (95% CI: 72-95) and 98% SP (95% CI: 88-100), and RDT-C 100% SN (95% CI: 88-100) and 98% SP (95% CI: 88-100). Against ELISA, SN and SP were above 90% for all three RDTs. CONCLUSIONS: RDT-A and RDT-C displayed IgG detection SN and SP above 90% in whole blood. These RDTs could be considered in the absence of routine diagnostic serology facilities.
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