Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.mehy.2020.110129 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110129 32721814!7373683!32721814     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32721814.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Med+Hypotheses 2020 ; 143 (ä): 110129 Nephropedia Template TP {{tp|p=32721814|t=2020. The war against the SARS-CoV2 infection: Is it better to fight or mitigate it?|pdf=|usr=}}{{32721814}} gab.com Text The war against the SARS-CoV2 infection: Is it better to fight or mitigate it JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32721814 #FOAvip In trying to understand the biochemical mechanism involved in the recent pandemic COVID-19, there is currently growing interest in angiotensin-converting enzyme II (ACE2). Nevertheless, the attempts to counteract COVID-19 interference with this enzymatic cascade are frustrating, and the results have thus far been inconclusive. Let's start again by considering the involved factors in an alternative way: we could postulate that COVID-19 could be more aggressive/fatal due to a high level of "basal" inflammation with low Nitric Oxide (NO) levels in hypertensive, diabetic and obese patients. Interestingly, the "protective" effects of several factors (such as estrogens) may play a role by increasing the formation of endogenous NO. From a therapeutic point of view, phosphodiesterase type 5 inhibitors such as oral Tadalafil, could be used in order to increase the basal NO levels. In this way, we don't fight the virus, but we may be able to mitigate its effects. Twit Text FOAVip The war against the SARS-CoV2 infection: Is it better to fight or mitigate it ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32721814 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32721814 #FOAvip English Wikipedia <ref>{{Cite pmid|32721814}}</ref> The war against the SARS-CoV2 infection: Is it better to fight or mitigate it? #MMPMID32721814 Dal Moro F; Vendramin I; Livi U Med Hypotheses 2020[Oct]; 143 (ä): 110129 PMID32721814show ga In trying to understand the biochemical mechanism involved in the recent pandemic COVID-19, there is currently growing interest in angiotensin-converting enzyme II (ACE2). Nevertheless, the attempts to counteract COVID-19 interference with this enzymatic cascade are frustrating, and the results have thus far been inconclusive. Let's start again by considering the involved factors in an alternative way: we could postulate that COVID-19 could be more aggressive/fatal due to a high level of "basal" inflammation with low Nitric Oxide (NO) levels in hypertensive, diabetic and obese patients. Interestingly, the "protective" effects of several factors (such as estrogens) may play a role by increasing the formation of endogenous NO. From a therapeutic point of view, phosphodiesterase type 5 inhibitors such as oral Tadalafil, could be used in order to increase the basal NO levels. In this way, we don't fight the virus, but we may be able to mitigate its effects. |*Pandemics[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/drug effects/*physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/complications/*drug therapy[MESH] |Cytokine Release Syndrome/etiology/physiopathology[MESH] |Estrogens/physiology[MESH] |Humans[MESH] |Hypertension/complications/physiopathology[MESH] |Inflammation[MESH] |Interleukins/physiology[MESH] |Models, Animal[MESH] |Models, Biological[MESH] |Nitric Oxide/*metabolism/therapeutic use[MESH] |Obesity/complications/physiopathology[MESH] |Off-Label Use[MESH] |Peptidyl-Dipeptidase A/drug effects/physiology[MESH] |Phosphodiesterase 5 Inhibitors/pharmacology/therapeutic use[MESH] |Pneumonia, Viral/complications/*drug therapy[MESH] |Receptors, Virus/drug effects/physiology[MESH] |SARS-CoV-2[MESH] |Sildenafil Citrate/pharmacology/therapeutic use[MESH]The war against the SARS-CoV2 infection: Is it better to fight or miti(epmc).pdf DeepDyve Pubget Overpricing