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10.1016/j.mehy.2020.110108

http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110108
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32721804!7358758!32721804
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suck abstract from ncbi


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pmid32721804      Med+Hypotheses 2020 ; 143 (ä): 110108
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  • Recombinant protein targeting and opsonizing spike glycoprotein for enhancing SARS-CoV-2 phagocytosis #MMPMID32721804
  • Khattabi L
  • Med Hypotheses 2020[Oct]; 143 (ä): 110108 PMID32721804show ga
  • The present hypothesis suggests an innovative therapeutic strategy to cease Covid 19 infection. It is based on the inhibition of Spike glycoprotein and ACE-2 receptor interaction that provides the entry of virus in human host cells, by targeting the S protein with a recombinant molecule made of the ACE-2 receptor ectodomain and an opsonin, the formed complex would enhance its phagocytosis.
  • |*Betacoronavirus[MESH]
  • |*Phagocytosis[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Drug Design[MESH]
  • |Humans[MESH]
  • |Opsonin Proteins/*chemistry[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/chemistry[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |Protein Domains[MESH]
  • |Protein Engineering[MESH]
  • |Recombinant Proteins/chemistry[MESH]
  • |SARS-CoV-2[MESH]
  • |Spike Glycoprotein, Coronavirus/*antagonists & inhibitors/chemistry[MESH]


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