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Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Gastroenterol+Hepatol 2021 ; 36 (3): 694-699 Nephropedia Template TP
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Clinical characteristics and outcomes of 2019 novel coronavirus disease patients presenting with initial gastrointestinal symptoms in Wuhan, China: A retrospective cohort study #MMPMID32721038
Luo S; Deng Z; Zhang X; Pan Z; Xu H
J Gastroenterol Hepatol 2021[Mar]; 36 (3): 694-699 PMID32721038show ga
BACKGROUND AND AIM: Patients with 2019 novel coronavirus disease (COVID-19) could present with gastrointestinal symptoms without fever or respiratory manifestations, which could be overlooked by health-care providers. We aimed to evaluate the clinical characteristics of COVID-19 in patients presenting with initial gastrointestinal symptoms. METHODS: We evaluated all confirmed cases of COVID-19 in Zhongnan Hospital of Wuhan University between January 10 and February 29, 2020. We divided these patients into two groups: patients with initial gastrointestinal symptoms (group A, n = 183) and patients with respiratory syndrome and/or fever (group B, n = 1228). The clinical characteristics, radiological features, and laboratory data were assessed. RESULTS: The clinical procedures of both groups underwent 1-2 weeks rising period and were downward trend at 3 weeks; less than 5% of patients progressed to critical illness. In both groups, mean leukocyte count (P = 0.354) and lymphocyte count (P = 0.386) were below normal, and C-reactive protein level was elevated (P = 0.412). There was mild liver function injury (aspartate aminotransferase, 65.8 +/- 12.7 vs 67.4 +/- 9.3 U/L, P = 0.246; alanine aminotransferase, 66.4 +/- 13.2 vs 69.6 +/- 12.7 U/L, P = 0.352), and normal renal function was intact (blood urea nitrogen 6.4 +/- 2.5 vs 5.6 +/- 2.8 mmol/L P = 0.358; creatinine 85.7 +/- 37.2, 91.2 +/- 32.6 mumol/L, P = 0.297). After a series of treatment, 176 and 1169 were stable and alive in groups A and B, respectively. The survival rate did not differ significantly between the groups (P = 0.313). CONCLUSION: COVID-19 patients presented with initial gastrointestinal symptoms had similar clinical characteristics and outcomes, when compared with patients with fever and respiratory symptoms.