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10.1093/ibd/izaa181

http://scihub22266oqcxt.onion/10.1093/ibd/izaa181
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32720978!7454647!32720978
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suck abstract from ncbi


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pmid32720978      Inflamm+Bowel+Dis 2020 ; 26 (9): 1306-1314
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  • The Thrilling Journey of SARS-CoV-2 into the Intestine: From Pathogenesis to Future Clinical Implications #MMPMID32720978
  • Scaldaferri F; Ianiro G; Privitera G; Lopetuso LR; Vetrone LM; Petito V; Pugliese D; Neri M; Cammarota G; Ringel Y; Costamagna G; Gasbarrini A; Boskoski I; Armuzzi A
  • Inflamm Bowel Dis 2020[Aug]; 26 (9): 1306-1314 PMID32720978show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has a direct impact on the gastrointestinal system, as up to 50% of fecal samples from coronavirus disease 2019 (COVID-19) patients contain detectable viral RNA despite a negative rhino-pharyngeal swab. This finding, together with an intestinal expression of angiotensin conversion enzyme 2 protein, suggests a possible fecal-oral transmission for SARS-CoV-2. Furthermore, gastrointestinal (GI) symptoms are common in COVID-19 patients including watery diarrhea, vomiting-particularly in children-nausea, and abdominal pain. Pathogenesis of SARS-CoV-2 infection presents significant similarities to those of some immune-mediated diseases, such as inflammatory bowel diseases or rheumatoid arthritis, leading to the hypothesis that targeted therapies used for the treatment of immune-mediated disease could be effective to treat (and possibly prevent) the main complications of COVID-19. In this review, we synthesize the present and future impact of SARS-CoV-2 infection on the gastrointestinal system and on gastroenterology practice, hypothesizing a potential role of the "gut-lung axis" and perhaps of the gut and lung microbiota into the interindividual differential susceptibility to COVID-19 19 disease. Finally, we speculate on the reorganization of outpatient gastroenterology services, which need to consider, among other factors, the major psychological impact of strict lockdown measures on the whole population.
  • |*Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/virology[MESH]
  • |Feces/virology[MESH]
  • |Gastrointestinal Diseases/*virology[MESH]
  • |Gastrointestinal Tract/virology[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/virology[MESH]
  • |RNA, Viral/analysis[MESH]


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