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10.1002/jmv.26361

http://scihub22266oqcxt.onion/10.1002/jmv.26361
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32720708!ä!32720708

suck abstract from ncbi


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pmid32720708      J+Med+Virol 2021 ; 93 (2): 945-951
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  • Longitudinal epidemiology of human coronavirus OC43 in Yamagata, Japan, 2010-2017: Two groups based on spike gene appear one after another #MMPMID32720708
  • Komabayashi K; Matoba Y; Tanaka S; Seto J; Aoki Y; Ikeda T; Shimotai Y; Matsuzaki Y; Itagaki T; Mizuta K
  • J Med Virol 2021[Feb]; 93 (2): 945-951 PMID32720708show ga
  • Human coronavirus OC43 (HCoV-OC43) is divided into genotypes A to H based on genetic recombination including the spike (S) gene. To investigate the longitudinal transition of the phylogenetic feature of the HCoV-OC43 S gene in a community, phylogenetic analysis of the S1 region of the S gene was conducted using 208 strains detected in Yamagata during 2010 to 2017 with reference strains of the genotype. The S1 sequences were divisible into four groups: A to D. All Yamagata strains belonged to either group B or group D. In group B, 46 (90.2%) out of 51 Yamagata strains were clustered with those of genotype E reference strains (cluster E). In group D, 28 (17.8%) and 122 (77.7%) out of 157 Yamagata strains were clustered, respectively, with genotype F and genotype G reference strains. In cluster G, 28 strains formed a distinct cluster. Monthly distributions of HCoV-OC43 in Yamagata in 2010 to 2017 revealed that group B and group D appeared one after another. In group B, the cluster E strains were prevalent recurrently. In conclusion, epidemics of HCoV-OC43 in Yamagata, Japan might be attributable to two genetically different groups: group B showed a recurrent epidemic of strains belonging to a single phylogenetic cluster and group D showed epidemic strains belonging to multiple clusters.
  • |*Genotype[MESH]
  • |*Phylogeny[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Coronavirus Infections/*epidemiology/virology[MESH]
  • |Coronavirus OC43, Human/classification/*genetics[MESH]
  • |Evolution, Molecular[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Longitudinal Studies[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |RNA, Viral/genetics[MESH]
  • |Recombination, Genetic[MESH]
  • |Sequence Analysis, DNA[MESH]
  • |Spike Glycoprotein, Coronavirus/*genetics[MESH]


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