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10.3389/fimmu.2020.01665

http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01665
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32719688!7350897!32719688
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suck abstract from ncbi


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pmid32719688      Front+Immunol 2020 ; 11 (ä): 1665
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  • Case Report: Systemic Inflammatory Response and Fast Recovery in a Pediatric Patient With COVID-19 #MMPMID32719688
  • Klocperk A; Parackova Z; Dissou J; Malcova H; Pavlicek P; Vymazal T; Dolezalova P; Sediva A
  • Front Immunol 2020[]; 11 (ä): 1665 PMID32719688show ga
  • We report a case of an 8-year-old girl who underwent a SARS-CoV-2 infection manifesting with atypical symptoms spearheaded by abdominal discomfort and systemic inflammation and partially mimicking hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS), which however did not fulfill the HLH/MAS diagnostic criteria. In this case of what has since been described as Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-COV-2 (PIMS-TS) we documented excellent clinical response to immunosuppression with systemic corticosteroids and intravenous immunoglobulins. We show a detailed longitudinal development of neutrophil immunophenotype which suggests activation and engagement of neutrophils during PIMS-TS with compensatory contraction of the response and contra-regulation of neutrophil phenotype during recovery.
  • |*Betacoronavirus/immunology/metabolism[MESH]
  • |*Coronavirus Infections/blood/diagnosis/drug therapy/immunology[MESH]
  • |*Immunosuppression Therapy[MESH]
  • |*Lymphohistiocytosis, Hemophagocytic/diagnosis/drug therapy/immunology[MESH]
  • |*Macrophage Activation Syndrome/diagnosis/drug therapy/immunology[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/blood/diagnosis/drug therapy/immunology[MESH]
  • |Adrenal Cortex Hormones/*administration & dosage[MESH]
  • |COVID-19[MESH]
  • |Child[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulins, Intravenous/*administration & dosage[MESH]
  • |Inflammation/diagnosis/drug therapy/immunology[MESH]
  • |Neutrophils[MESH]


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