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10.4103/ijmm.IJMM_20_133

http://scihub22266oqcxt.onion/10.4103/ijmm.IJMM_20_133
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suck abstract from ncbi


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pmid32719214      Indian+J+Med+Microbiol 2020 ; 38 (1): 87-93
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  • Comparative analysis of clinical characteristics, imaging and laboratory findings of different age groups with COVID-19 #MMPMID32719214
  • Liu X; Lv J; Gan L; Zhang Y; Sun F; Meng B; Jheon A; Yan F; Li B; Xuan Z; Ma X; Wulasihana M
  • Indian J Med Microbiol 2020[Jan]; 38 (1): 87-93 PMID32719214show ga
  • OBJECTIVE: This study aims to provide scientific basis for rapid screening and early diagnosis of the coronavirus disease 2019 (COVID-19) through analysing the clinical characteristics and early imaging/laboratory findings of the inpatients. METHODS: Three hundred and three patients with laboratory-confirmed COVID-19 from the East Hospital of People's Hospital of Wuhan University (Wuhan, China) were selected and divided into four groups: youth (20-40 years, n = 64), middle-aged (41-60 years, n = 89), older (61-80 years, n = 118) and elderly (81-100 years, n = 32). The clinical characteristics and imaging/laboratory findings including chest computed tomography (CT), initial blood count, C-reactive protein [CRP]), procalcitonin (PCT) and serum total IgE were captured and analysed. RESULTS: (1) The first symptoms of all age groups were primarily fever (76%), followed by cough (12%) and dyspnoea (5%). Beside fever, the most common initial symptom of elderly patients was fatigue (13%). (2) Fever was the most common clinical manifestation (80%), with moderate fever being the most common (40%), followed by low fever in patients above 40 years old and high fever in those under 40 years (35%). Cough was the second most common clinical manifestation and was most common (80%) in the middle-aged. Diarrhoea was more common in the middle-aged (21%) and the older (19%). Muscle ache was more common in the middle-aged (15%). Chest pain was more common in the youth (13%), and 13% of the youth had no symptoms. (3) The proportion of patients with comorbidities increased with age. (4) Seventy-one per cent of the patients had positive reverse transcription-polymerase chain reaction results and 29% had positive chest CT scans before admission to the hospital. (5) Lesions in all lobes of the lung were observed as the main chest CT findings (76%). (6) Decrease in lymphocytes and increase in monocytes were common in the patients over 40 years old but rare in the youth. Eosinophils (50%), red blood cells (39%) and haemoglobin (40%) decreased in all age groups. (7) The proportion of patients with CRP and PCT elevation increased with age. (8) Thirty-nine per cent of the patients had elevated IgE, with the highest proportion in the old (49%). CONCLUSION: The clinical characteristics and imaging/laboratory findings of COVID-19 patients vary in different age groups. Personalised criteria should be formulated according to different age groups in the early screening and diagnosis stage.
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus/*growth & development[MESH]
  • |COVID-19[MESH]
  • |China[MESH]
  • |Clinical Laboratory Techniques/*methods[MESH]
  • |Coronavirus Infections/*diagnosis/diagnostic imaging/*pathology[MESH]
  • |Diagnostic Tests, Routine/*methods[MESH]
  • |Early Diagnosis[MESH]
  • |Female[MESH]
  • |Hospitals, University[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Mass Screening/methods[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis/diagnostic imaging/*pathology[MESH]
  • |SARS-CoV-2[MESH]
  • |Tomography, X-Ray Computed/*methods[MESH]


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