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10.1136/annrheumdis-2020-218048

http://scihub22266oqcxt.onion/10.1136/annrheumdis-2020-218048
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suck abstract from ncbi


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pmid32719039      Ann+Rheum+Dis 2020 ; 79 (9): 1152-1155
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  • Lung involvement in macrophage activation syndrome and severe COVID-19: results from a cross-sectional study to assess clinical, laboratory and artificial intelligence-radiological differences #MMPMID32719039
  • Ruscitti P; Bruno F; Berardicurti O; Acanfora C; Pavlych V; Palumbo P; Conforti A; Carubbi F; Di Cola I; Di Benedetto P; Cipriani P; Grassi D; Masciocchi C; Iagnocco A; Barile A; Giacomelli R
  • Ann Rheum Dis 2020[Sep]; 79 (9): 1152-1155 PMID32719039show ga
  • OBJECTIVES: To evaluate the clinical pictures, laboratory tests and imaging of patients with lung involvement, either from severe COVID-19 or macrophage activation syndrome (MAS), in order to assess how similar these two diseases are. METHODS: The present work has been designed as a cross-sectional single-centre study to compare characteristics of patients with lung involvement either from MAS or severe COVID-19. Chest CT scans were assessed by using an artificial intelligence (AI)-based software. RESULTS: Ten patients with MAS and 47 patients with severe COVID-19 with lung involvement were assessed. Although all patients showed fever and dyspnoea, patients with MAS were characterised by thrombocytopaenia, whereas patients with severe COVID-19 were characterised by lymphopaenia and neutrophilia. Higher values of H-score characterised patients with MAS when compared with severe COVID-19. AI-reconstructed images of chest CT scan showed that apical, basal, peripheral and bilateral distributions of ground-glass opacities (GGOs), as well as apical consolidations, were more represented in severe COVID-19 than in MAS. C reactive protein directly correlated with GGOs extension in both diseases. Furthermore, lymphopaenia inversely correlated with GGOs extension in severe COVID-19. CONCLUSIONS: Our data could suggest laboratory and radiological differences between MAS and severe COVID-19, paving the way for further hypotheses to be investigated in future confirmatory studies.
  • |*Betacoronavirus[MESH]
  • |Aged[MESH]
  • |Artificial Intelligence[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*diagnostic imaging/pathology/virology[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lung/diagnostic imaging/pathology/virology[MESH]
  • |Macrophage Activation Syndrome/*diagnostic imaging/pathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnostic imaging/pathology/virology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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