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10.1016/j.medcli.2020.06.026

http://scihub22266oqcxt.onion/10.1016/j.medcli.2020.06.026
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suck abstract from ncbi


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pmid32718719      Med+Clin+(Barc) 2020 ; 155 (7): 281-287
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  • Interacciones medicamentosas potenciales en pacientes COVID 19 en tratamiento con lopinavir/ritonavir #MMPMID32718719
  • Brandariz-Nunez D; Correas-Sanahuja M; Guarc E; Picon R; Garcia B; Gil R
  • Med Clin (Barc) 2020[Oct]; 155 (7): 281-287 PMID32718719show ga
  • OBJECTIVES: To determine the prevalence of potential interactions in COVID-19 patients receiving lopinavir/ritonavir (LPV/r). The secondary objective was to develop recommendations and identify the risk factors associated with presenting potential interactions with LPV/r. SUBJECTS AND METHODS: Cross-sectional and multicenter study with the participation of 2 hospitals. COVID-19 patients over 18 years of age, admitted to hospital and under treatment with LPV/r were included. A screening of potential interactions related to LPV/r and home and hospital medication was carried out. Lexicomp(R) (Uptodate), HIV-drug interactions and COVID-drug interactions were used as the query database. RESULTS: 361 patients with a mean age of 62.77 +/- 14.64 years were included, where 59.6% (n = 215) were men. 62.3% (n = 225) had 1 or more potential interactions and 26, 87% (n = 97) 2 or more. The independent variables associated with presenting >/=1 potential interactions were age (> 65) (OR 1.95; 95% CI 1.06-3.59, P =.033), ICU admission (OR 9.22; CI 95% 1.98-42.93; P =.005), previous respiratory pathology (OR 2.90; 95% CI 1.15-7.36; P =.024), psychiatric (OR 4.14; 95 CI % 1.36-12.61; P =.013), dyslipidemia (OR 3.21; 95% CI 1.63-6.35; P =.001) and the number of drugs prescribed (OR 4.33; 95% CI 2.40-7.81; P =.000). CONCLUSION: The prevalence of potential interactions in COVD-19 patient undergoing treatment with LPV/r is high, with age (> 65), ICU admission, previous respiratory and psychiatric pathology, dyslipidemia and the number of prescribed drugs acting as risk factors.
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antiviral Agents/*adverse effects/therapeutic use[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Drug Combinations[MESH]
  • |Drug Interactions[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lopinavir/*adverse effects/therapeutic use[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |Risk Factors[MESH]
  • |Ritonavir/*adverse effects/therapeutic use[MESH]
  • |SARS-CoV-2[MESH]


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