Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.bbi.2020.07.026 http://scihub22266oqcxt.onion/10.1016/j.bbi.2020.07.026 32717399!7378483!32717399     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brain+Behav+Immun 2020 ; 89 (ä): 480-490 Nephropedia Template TP {{tp|p=32717399|t=2020. Purinergic signaling in infectious diseases of the central nervous system |pdf=|usr=}}{{32717399}} gab.com Text Purinergic signaling in infectious diseases of the central nervous system JO: Brain Behav Immun http://www.kidney.de/pget.php?&tw=1&pmid=32717399 #FOAvip The incidence of infectious diseases affecting the central nervous system (CNS) has been increasing over the last several years. Among the reasons for the expansion of these diseases and the appearance of new neuropathogens are globalization, global warming, and the increased proximity between humans and wild animals due to human activities such as deforestation. Neurotropism affecting normal brain function is shared by organisms such as viruses, bacteria, fungi, and parasites. Neuroinfections caused by these agents activate immune responses, inducing neuroinflammation, excitotoxicity, and neurodegeneration. Purinergic signaling is an evolutionarily conserved signaling pathway associated with these neuropathologies. During neuroinfections, host cells release ATP as an extracellular danger signal with pro-inflammatory activities. ATP is metabolized to its derivatives by ectonucleotidases such as CD39 and CD73; ATP and its metabolites modulate neuronal and immune mechanisms through P1 and P2 purinergic receptors that are involved in pathophysiological mechanisms of neuroinfections. In this review we discuss the beneficial or deleterious effects of various components of the purinergic signaling pathway in infectious diseases that affect the CNS, including human immunodeficiency virus (HIV-1) infection, herpes simplex virus type 1 (HSV-1) infection, bacterial meningitis, sepsis, cryptococcosis, toxoplasmosis, and malaria. We also provide a description of this signaling pathway in emerging viral infections with neurological implications such as Zika and SARS-CoV-2. Twit Text FOAVip Purinergic signaling in infectious diseases of the central nervous system ????Brain Behav Immun http://www.kidney.de/pget.php?&tw=1&pmid=32717399 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32717399 #FOAvip English Wikipedia <ref>{{Cite pmid|32717399}}</ref> Purinergic signaling in infectious diseases of the central nervous system #MMPMID32717399 Alves VS; Leite-Aguiar R; Silva JPD; Coutinho-Silva R; Savio LEB Brain Behav Immun 2020[Oct]; 89 (ä): 480-490 PMID32717399show ga The incidence of infectious diseases affecting the central nervous system (CNS) has been increasing over the last several years. Among the reasons for the expansion of these diseases and the appearance of new neuropathogens are globalization, global warming, and the increased proximity between humans and wild animals due to human activities such as deforestation. Neurotropism affecting normal brain function is shared by organisms such as viruses, bacteria, fungi, and parasites. Neuroinfections caused by these agents activate immune responses, inducing neuroinflammation, excitotoxicity, and neurodegeneration. Purinergic signaling is an evolutionarily conserved signaling pathway associated with these neuropathologies. During neuroinfections, host cells release ATP as an extracellular danger signal with pro-inflammatory activities. ATP is metabolized to its derivatives by ectonucleotidases such as CD39 and CD73; ATP and its metabolites modulate neuronal and immune mechanisms through P1 and P2 purinergic receptors that are involved in pathophysiological mechanisms of neuroinfections. In this review we discuss the beneficial or deleterious effects of various components of the purinergic signaling pathway in infectious diseases that affect the CNS, including human immunodeficiency virus (HIV-1) infection, herpes simplex virus type 1 (HSV-1) infection, bacterial meningitis, sepsis, cryptococcosis, toxoplasmosis, and malaria. We also provide a description of this signaling pathway in emerging viral infections with neurological implications such as Zika and SARS-CoV-2. |AIDS Dementia Complex/metabolism[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Central Nervous System Infections/*metabolism[MESH] |Coronavirus Infections/metabolism[MESH] |Encephalitis, Herpes Simplex/metabolism[MESH] |Humans[MESH] |Malaria/metabolism[MESH] |Meningitis, Bacterial/metabolism[MESH] |Meningitis, Cryptococcal/metabolism[MESH] |Pandemics[MESH] |Pneumonia, Viral/metabolism[MESH] |Receptors, Purinergic P1/*metabolism[MESH] |Receptors, Purinergic P2X/*metabolism[MESH] |Receptors, Purinergic P2Y/*metabolism[MESH] |SARS-CoV-2[MESH] |Sepsis/metabolism[MESH] |Signal Transduction[MESH] |Toxoplasmosis, Cerebral/metabolism[MESH]Purinergic signaling in infectious diseases of the central nervous sys(epmc).pdf DeepDyve Pubget Overpricing