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10.2139/ssrn.3575161 http://scihub22266oqcxt.onion/10.2139/ssrn.3575161 32714112!7366814!32714112     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       SSRN 2020 ; ä (ä): 3575161 Nephropedia Template TP {{tp|p=32714112|t=2020. A SARS-CoV-2 Vaccination Strategy Focused on Population-Scale Immunity |pdf=|usr=}}{{32714112}} gab.com Text A SARS-CoV-2 Vaccination Strategy Focused on Population-Scale Immunity JO: SSRN http://www.kidney.de/pget.php?&tw=1&pmid=32714112 #FOAvip Here we propose a vaccination strategy for SARS-CoV-2 based on identification of both highly conserved regions of the virus and newly acquired adaptations that are presented by MHC class I and II across the vast majority of the population, are highly dissimilar from the human proteome, and are predicted B cell epitopes. We present 65 peptide sequences that we expect to result in a safe and effective vaccine which can be rapidly tested in DNA, mRNA, or synthetic peptide constructs. These include epitopes that are contained within evolutionarily divergent regions of the spike protein reported to increase infectivity through increased binding to the ACE2 receptor, and within a novel furin cleavage site thought to increase membrane fusion. This vaccination strategy specifically targets unique vulnerabilities of SARS-CoV-2 and should engage a robust adaptive immune response in the vast majority of the human population. Twit Text FOAVip A SARS-CoV-2 Vaccination Strategy Focused on Population-Scale Immunity ????SSRN http://www.kidney.de/pget.php?&tw=1&pmid=32714112 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32714112 #FOAvip English Wikipedia <ref>{{Cite pmid|32714112}}</ref> A SARS-CoV-2 Vaccination Strategy Focused on Population-Scale Immunity #MMPMID32714112 Yarmarkovich M; Warrington JM; Farrel A; Maris JM SSRN 2020[Apr]; ä (ä): 3575161 PMID32714112show ga Here we propose a vaccination strategy for SARS-CoV-2 based on identification of both highly conserved regions of the virus and newly acquired adaptations that are presented by MHC class I and II across the vast majority of the population, are highly dissimilar from the human proteome, and are predicted B cell epitopes. We present 65 peptide sequences that we expect to result in a safe and effective vaccine which can be rapidly tested in DNA, mRNA, or synthetic peptide constructs. These include epitopes that are contained within evolutionarily divergent regions of the spike protein reported to increase infectivity through increased binding to the ACE2 receptor, and within a novel furin cleavage site thought to increase membrane fusion. This vaccination strategy specifically targets unique vulnerabilities of SARS-CoV-2 and should engage a robust adaptive immune response in the vast majority of the human population. äA SARS-CoV-2 Vaccination Strategy Focused on Population-Scale Immunity(epmc).pdf DeepDyve Pubget Overpricing