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10.1111/ajt.16223 http://scihub22266oqcxt.onion/10.1111/ajt.16223 32713123!9800697!32713123     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transplant 2020 ; 20 (11): 3216-3220 Nephropedia Template TP {{tp|p=32713123|t=2020. Allograft infiltration and meningoencephalitis by SARS-CoV-2 in a pancreas-kidney transplant recipient |pdf=|usr=}}{{32713123}} gab.com Text Allograft infiltration and meningoencephalitis by SARS-CoV-2 in a pancreas-kidney transplant recipient JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=32713123 #FOAvip Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) preferentially affects epithelia of the upper and lower respiratory tract. Thus, impairment of kidney function has been primarily attributed until now to secondary effects such as cytokine release or fluid balance disturbances. We provide evidence that SARS-CoV-2 can directly infiltrate a kidney allograft. A 69-year-old male, who underwent pancreas-kidney transplantation 13 years previously, presented to our hospital with coronavirus disease 2019 (COVID-19) pneumonia and impaired pancreas and kidney allograft function. Kidney biopsy was performed showing tubular damage and an interstitial mononuclear cell infiltrate. Reverse transcriptase polymerase chain reaction from the biopsy specimen was positive for SARS-CoV-2. In-situ hybridization revealed SARS-CoV-2 RNA in tubular cells and the interstitium. Subsequently, he had 2 convulsive seizures. Magnetic resonance tomography suggested meningoencephalitis, which was confirmed by SARS-CoV-2 RNA transcripts in the cerebrospinal fluid. The patient had COVID-19 pneumonia, meningoencephalitis, and nephritis. SARS-CoV-2 binds to its target cells through angiotensin-converting enzyme 2, which is expressed in a broad variety of tissues including the lung, brain, and kidney. SARS-CoV-2 thereby shares features with other human coronaviruses including SARS-CoV that were identified as pathogens beyond the respiratory tract as well. The present case should provide awareness that extrapulmonary symptoms in COVID-19 may be attributable to viral infiltration of diverse organs. Twit Text FOAVip Allograft infiltration and meningoencephalitis by SARS-CoV-2 in a pancreas-kidney transplant recipient ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=32713123 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32713123 #FOAvip English Wikipedia <ref>{{Cite pmid|32713123}}</ref> Allograft infiltration and meningoencephalitis by SARS-CoV-2 in a pancreas-kidney transplant recipient #MMPMID32713123 Westhoff TH; Seibert FS; Bauer F; Stervbo U; Anft M; Doevelaar AAN; Rohn BJ; Winnekendonk G; Dittmer U; Schenker P; Vonbrunn E; Amann K; Viebahn R; Babel N Am J Transplant 2020[Nov]; 20 (11): 3216-3220 PMID32713123show ga Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) preferentially affects epithelia of the upper and lower respiratory tract. Thus, impairment of kidney function has been primarily attributed until now to secondary effects such as cytokine release or fluid balance disturbances. We provide evidence that SARS-CoV-2 can directly infiltrate a kidney allograft. A 69-year-old male, who underwent pancreas-kidney transplantation 13 years previously, presented to our hospital with coronavirus disease 2019 (COVID-19) pneumonia and impaired pancreas and kidney allograft function. Kidney biopsy was performed showing tubular damage and an interstitial mononuclear cell infiltrate. Reverse transcriptase polymerase chain reaction from the biopsy specimen was positive for SARS-CoV-2. In-situ hybridization revealed SARS-CoV-2 RNA in tubular cells and the interstitium. Subsequently, he had 2 convulsive seizures. Magnetic resonance tomography suggested meningoencephalitis, which was confirmed by SARS-CoV-2 RNA transcripts in the cerebrospinal fluid. The patient had COVID-19 pneumonia, meningoencephalitis, and nephritis. SARS-CoV-2 binds to its target cells through angiotensin-converting enzyme 2, which is expressed in a broad variety of tissues including the lung, brain, and kidney. SARS-CoV-2 thereby shares features with other human coronaviruses including SARS-CoV that were identified as pathogens beyond the respiratory tract as well. The present case should provide awareness that extrapulmonary symptoms in COVID-19 may be attributable to viral infiltration of diverse organs. |*Postoperative Complications[MESH] |Aged[MESH] |COVID-19/*epidemiology[MESH] |Comorbidity[MESH] |Humans[MESH] |Kidney Transplantation/*adverse effects[MESH] |Male[MESH] |Meningoencephalitis/diagnosis/*epidemiology[MESH] |Pancreas Transplantation/*adverse effects[MESH] |Pandemics[MESH] |RNA, Viral/*genetics[MESH] |SARS-CoV-2/*genetics[MESH] |Transplant Recipients[MESH]Allograft infiltration and meningoencephalitis by SARS-CoV-2 in a panc(epmc).pdf DeepDyve Pubget Overpricing