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10.1111/1751-2980.12925 http://scihub22266oqcxt.onion/10.1111/1751-2980.12925 32713118!ä!32713118 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Dig+Dis 2020 ; 21 (9): 512-518 Nephropedia Template TP {{tp|p=32713118|t=2020. Liver damage at admission is an independent prognostic factor for COVID-19 |pdf=|usr=}}{{32713118}} gab.com Text Liver damage at admission is an independent prognostic factor for COVID-19 JO: J Dig Dis http://www.kidney.de/pget.php?&tw=1&pmid=32713118 #FOAvip OBJECTIVE: Abnormal liver function is a common form of extra-pulmonary organ damage in patients with coronavirus disease 2019 (COVID-19). Patients with severe COVID-19 have a higher probability and progression of liver injury than those without severe disease. We aimed to evaluate the prognosis of liver injury in patients with COVID-19. METHODS: We retrospectively included 502 patients with laboratory-confirmed SARS-CoV-2 infection. Clinical features and survival of patients with and without liver injury were compared. Cox proportional hazards models were used to determine the variables that might have an effect on survival. RESULTS: Among the 502 patients enrolled, 301 patients had abnormal liver function with increased neutrophil count, C-reactive protein, creatinine, troponin I (TnI), D-dimer, lactose dehydrogenase and creatine kinase. Patients with abnormal liver functions had a higher mortality rate (28.9% vs 9.0%, P < 0.001), a higher ratio of male sex (65.1% vs 40.8%, P < 0.001) and a higher chance of developing systemic inflammatory response syndrome (53.5% vs 41.3%, P = 0.007). Among patients with abnormal liver functions, patients with grade 2 liver damage (with both abnormal alanine aminotransferase or aspartate aminotransferase levels and abnormal alkaline phosphatase or gamma-glutamyl transpeptidase levels) had a higher ratio of male patients, elevated neutrophil count, procalcitonin, D-dimer levels and mortality rate. Multivariate Cox regression analyses suggested that the grade of liver damage (hazard ratio: 1.377, 95% confidence interval: 1.000-1.896, P = 0.049) was an independent predictor of death. CONCLUSIONS: Patients with COVID-19 and abnormal liver functions have a higher mortality than those with normal liver functions. Liver damage is an independent prognostic factor of COVID-19. Twit Text FOAVip Liver damage at admission is an independent prognostic factor for COVID-19 ????J Dig Dis http://www.kidney.de/pget.php?&tw=1&pmid=32713118 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32713118 #FOAvip English Wikipedia <ref>{{Cite pmid|32713118}}</ref> Liver damage at admission is an independent prognostic factor for COVID-19 #MMPMID32713118 Chen LY; Chu HK; Bai T; Tu SJ; Wei Y; Li ZL; Hu LL; Zhu R; Zhang L; Han CQ; Xiao L; He Q; Song J; Liu WH; Zhu QJ; Chen H; Yang L; Hou XH J Dig Dis 2020[Sep]; 21 (9): 512-518 PMID32713118show ga OBJECTIVE: Abnormal liver function is a common form of extra-pulmonary organ damage in patients with coronavirus disease 2019 (COVID-19). Patients with severe COVID-19 have a higher probability and progression of liver injury than those without severe disease. We aimed to evaluate the prognosis of liver injury in patients with COVID-19. METHODS: We retrospectively included 502 patients with laboratory-confirmed SARS-CoV-2 infection. Clinical features and survival of patients with and without liver injury were compared. Cox proportional hazards models were used to determine the variables that might have an effect on survival. RESULTS: Among the 502 patients enrolled, 301 patients had abnormal liver function with increased neutrophil count, C-reactive protein, creatinine, troponin I (TnI), D-dimer, lactose dehydrogenase and creatine kinase. Patients with abnormal liver functions had a higher mortality rate (28.9% vs 9.0%, P < 0.001), a higher ratio of male sex (65.1% vs 40.8%, P < 0.001) and a higher chance of developing systemic inflammatory response syndrome (53.5% vs 41.3%, P = 0.007). Among patients with abnormal liver functions, patients with grade 2 liver damage (with both abnormal alanine aminotransferase or aspartate aminotransferase levels and abnormal alkaline phosphatase or gamma-glutamyl transpeptidase levels) had a higher ratio of male patients, elevated neutrophil count, procalcitonin, D-dimer levels and mortality rate. Multivariate Cox regression analyses suggested that the grade of liver damage (hazard ratio: 1.377, 95% confidence interval: 1.000-1.896, P = 0.049) was an independent predictor of death. CONCLUSIONS: Patients with COVID-19 and abnormal liver functions have a higher mortality than those with normal liver functions. Liver damage is an independent prognostic factor of COVID-19. |*Coronavirus Infections/blood/diagnosis/mortality/physiopathology[MESH] |*Hepatic Insufficiency/blood/diagnosis/etiology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/blood/diagnosis/mortality/physiopathology[MESH] |Alanine Transaminase/*blood[MESH] |Aspartate Aminotransferases/*blood[MESH] |Betacoronavirus/isolation & purification[MESH] |C-Reactive Protein/*analysis[MESH] |COVID-19[MESH] |China/epidemiology[MESH] |Female[MESH] |Fibrin Fibrinogen Degradation Products/*analysis[MESH] |Humans[MESH] |Leukocyte Count/methods[MESH] |Male[MESH] |Middle Aged[MESH] |Mortality[MESH] |Outcome and Process Assessment, Health Care[MESH] |Procalcitonin/blood[MESH] |Prognosis[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]Liver damage at admission is an independent prognostic factor for COVI(epmc).pdf DeepDyve Pubget Overpricing