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10.1159/000509517 http://scihub22266oqcxt.onion/10.1159/000509517 32712607!7445371!32712607     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Blood+Press+Res 2020 ; 45 (4): 612-622 Nephropedia Template TP {{tp|p=32712607|t=2020. Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study |pdf=|usr=}}{{32712607}} gab.com Text Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study JO: Kidney Blood Press Res http://www.kidney.de/pget.php?&tw=1&pmid=32712607 #FOAvip INTRODUCTION: Severe acute respiratory viral infections are frequency accompanied by multiple organ dysfunction, including acute kidney injury (AKI). In December 2019, the coronavirus disease 2019 (COVID-19) outbreak began in Wuhan, Hubei Province, China, and rapidly spread worldwide. While diffuse alveolar damage and acute respiratory failure are the main features of COVID-19, other organs may be involved, and the incidence of AKI is not well described. We assessed the incidence and clinical characteristics of AKI in patients with laboratory-confirmed COVID-19 and its effects on clinical outcomes. METHODS: We conducted a multicenter, retrospective, observational study of patients with COVID-19 admitted to two general hospitals in Wuhan from 5 January 2020 to 21 March 2020. Demographic data and information on organ dysfunction were collected daily. AKI was defined according to the KDIGO clinical practice guidelines. Early and late AKI were defined as AKI occurring within 72 h after admission or after 72 h, respectively. RESULTS: Of the 116 patients, AKI developed in 21 (18.1%) patients. Among them, early and late AKI were found in 13 (11.2%) and 8 (6.9%) patients, respectively. Compared with patients without AKI, patients with AKI had more severe organ dysfunction, as indicated by a higher level of disease severity status, higher sequential organ failure assessment (SOFA) score on admission, an increased prevalence of shock, and a higher level of respiratory support. Patients with AKI had a higher SOFA score on admission (4.5 +/- 2.1 vs. 2.8 +/- 1.4, OR 1.498, 95% CI 1.047-2.143 ) and greater hospital mortality (57.1% vs. 12.6%, OR 3.998, 95% CI 1.088-14.613) than patients without AKI in both the univariate and multivariate analyses. Patients with late AKI, but not those with early AKI, had a significantly prolonged length of stay (19.6 vs. 9.6 days, p = 0.015). CONCLUSION: Our findings show that admission SOFA score was an independent risk factor for AKI in COVID-19 patients, and patients with AKI had higher in-hospital mortality. Moreover, AKI development after 72 h of admission was related to prolonged hospitalization time. Twit Text FOAVip Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study ????Kidney Blood Press Res http://www.kidney.de/pget.php?&tw=1&pmid=32712607 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32712607 #FOAvip English Wikipedia <ref>{{Cite pmid|32712607}}</ref> Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study #MMPMID32712607 Cui X; Yu X; Wu X; Huang L; Tian Y; Huang X; Zhang Z; Cheng Z; Guo Q; Zhang Y; Cai Y; Zhan Q Kidney Blood Press Res 2020[]; 45 (4): 612-622 PMID32712607show ga INTRODUCTION: Severe acute respiratory viral infections are frequency accompanied by multiple organ dysfunction, including acute kidney injury (AKI). In December 2019, the coronavirus disease 2019 (COVID-19) outbreak began in Wuhan, Hubei Province, China, and rapidly spread worldwide. While diffuse alveolar damage and acute respiratory failure are the main features of COVID-19, other organs may be involved, and the incidence of AKI is not well described. We assessed the incidence and clinical characteristics of AKI in patients with laboratory-confirmed COVID-19 and its effects on clinical outcomes. METHODS: We conducted a multicenter, retrospective, observational study of patients with COVID-19 admitted to two general hospitals in Wuhan from 5 January 2020 to 21 March 2020. Demographic data and information on organ dysfunction were collected daily. AKI was defined according to the KDIGO clinical practice guidelines. Early and late AKI were defined as AKI occurring within 72 h after admission or after 72 h, respectively. RESULTS: Of the 116 patients, AKI developed in 21 (18.1%) patients. Among them, early and late AKI were found in 13 (11.2%) and 8 (6.9%) patients, respectively. Compared with patients without AKI, patients with AKI had more severe organ dysfunction, as indicated by a higher level of disease severity status, higher sequential organ failure assessment (SOFA) score on admission, an increased prevalence of shock, and a higher level of respiratory support. Patients with AKI had a higher SOFA score on admission (4.5 +/- 2.1 vs. 2.8 +/- 1.4, OR 1.498, 95% CI 1.047-2.143 ) and greater hospital mortality (57.1% vs. 12.6%, OR 3.998, 95% CI 1.088-14.613) than patients without AKI in both the univariate and multivariate analyses. Patients with late AKI, but not those with early AKI, had a significantly prolonged length of stay (19.6 vs. 9.6 days, p = 0.015). CONCLUSION: Our findings show that admission SOFA score was an independent risk factor for AKI in COVID-19 patients, and patients with AKI had higher in-hospital mortality. Moreover, AKI development after 72 h of admission was related to prolonged hospitalization time. |Acute Kidney Injury/*etiology/mortality/*therapy[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19[MESH] |China/epidemiology[MESH] |Coronavirus Infections/*complications/mortality/therapy[MESH] |Disease Progression[MESH] |Female[MESH] |Hospital Mortality[MESH] |Hospitals, General[MESH] |Humans[MESH] |Incidence[MESH] |Kidney Function Tests[MESH] |Length of Stay[MESH] |Male[MESH] |Middle Aged[MESH] |Multiple Organ Failure/etiology/therapy[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/mortality/therapy[MESH] |Practice Guidelines as Topic[MESH] |Retrospective Studies[MESH] |Treatment Outcome[MESH]Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A M(epmc).pdf DeepDyve Pubget Overpricing