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10.1016/j.niox.2020.07.005 http://scihub22266oqcxt.onion/10.1016/j.niox.2020.07.005 32712272!7377740!32712272     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nitric+Oxide 2020 ; 103 (ä): 29-30 Nephropedia Template TP {{tp|p=32712272|t=2020. Blood nitrate and nitrite modulating nitric oxide bioavailability: Potential therapeutic functions in COVID-19 |pdf=|usr=}}{{32712272}} gab.com Text Blood nitrate and nitrite modulating nitric oxide bioavailability: Potential therapeutic functions in COVID-19 JO: Nitric Oxide http://www.kidney.de/pget.php?&tw=1&pmid=32712272 #FOAvip Most outcomes of COVID-19 are associated with dysfunction of the vascular system, particularly in the lung. Inhalation of nitric oxide (NO) gas is currently being investigated as a treatment for patients with moderate to severe COVID-19. In addition to the expected vasodilation effect, it has been also suggested that NO potentially prevents infection by SARS-CoV-2. Since NO is an unstable radical molecule that is easily oxidized by multiple mechanisms in the human body, it is practically difficult to control its concentration at lesions that need NO. Inorganic nitrate and/or nitrite are known as precursors of NO that can be produced through chemical as well enzymatic reduction. It appears that this NO synthase (NOS)-independent mechanism has been overlooked in the current developing of clinical treatments. Here, I suggest the missing link between nitrate and COVID-19 in terms of hypoxic NO generation. Twit Text FOAVip Blood nitrate and nitrite modulating nitric oxide bioavailability: Potential therapeutic functions in COVID-19 ????Nitric Oxide http://www.kidney.de/pget.php?&tw=1&pmid=32712272 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32712272 #FOAvip English Wikipedia <ref>{{Cite pmid|32712272}}</ref> Blood nitrate and nitrite modulating nitric oxide bioavailability: Potential therapeutic functions in COVID-19 #MMPMID32712272 Yamasaki H Nitric Oxide 2020[Oct]; 103 (ä): 29-30 PMID32712272show ga Most outcomes of COVID-19 are associated with dysfunction of the vascular system, particularly in the lung. Inhalation of nitric oxide (NO) gas is currently being investigated as a treatment for patients with moderate to severe COVID-19. In addition to the expected vasodilation effect, it has been also suggested that NO potentially prevents infection by SARS-CoV-2. Since NO is an unstable radical molecule that is easily oxidized by multiple mechanisms in the human body, it is practically difficult to control its concentration at lesions that need NO. Inorganic nitrate and/or nitrite are known as precursors of NO that can be produced through chemical as well enzymatic reduction. It appears that this NO synthase (NOS)-independent mechanism has been overlooked in the current developing of clinical treatments. Here, I suggest the missing link between nitrate and COVID-19 in terms of hypoxic NO generation. |Antiviral Agents/metabolism[MESH] |Ascorbic Acid/chemistry/therapeutic use[MESH] |Betacoronavirus/*drug effects[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/*drug therapy/metabolism/prevention & control[MESH] |Endothelium-Dependent Relaxing Factors/metabolism[MESH] |Humans[MESH] |Nitrates/blood/*metabolism[MESH] |Nitric Oxide/*metabolism[MESH] |Nitrites/blood/chemistry/*metabolism[MESH] |Pandemics/prevention & control[MESH] |Pneumonia, Viral/*drug therapy/metabolism/prevention & control[MESH] |SARS-CoV-2[MESH]Blood nitrate and nitrite modulating nitric oxide bioavailability: Pot(epmc).pdf DeepDyve Pubget Overpricing