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10.1016/bs.aivir.2020.06.003 http://scihub22266oqcxt.onion/10.1016/bs.aivir.2020.06.003 32711735!7326460!32711735     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Virus+Res 2020 ; 107 (ä): 383-416 Nephropedia Template TP {{tp|p=32711735|t=2020. Reverse genetic systems: Rational design of coronavirus live attenuated vaccines with immune sequelae |pdf=|usr=}}{{32711735}} gab.com Text Reverse genetic systems: Rational design of coronavirus live attenuated vaccines with immune sequelae JO: Adv Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=32711735 #FOAvip Since the end of 2019, the global COVID-19 outbreak has once again made coronaviruses a hot topic. Vaccines are hoped to be an effective way to stop the spread of the virus. However, there are no clinically approved vaccines available for coronavirus infections. Reverse genetics technology can realize the operation of RNA virus genomes at the DNA level and provide new ideas and strategies for the development of new vaccines. In this review, we systematically describe the role of reverse genetics technology in studying the effects of coronavirus proteins on viral virulence and innate immunity, cell and tissue tropism and antiviral drug screening. An efficient reverse genetics platform is useful for obtaining the ideal attenuated strain to prepare an attenuated live vaccine. Twit Text FOAVip Reverse genetic systems: Rational design of coronavirus live attenuated vaccines with immune sequelae ????Adv Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=32711735 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32711735 #FOAvip English Wikipedia <ref>{{Cite pmid|32711735}}</ref> Reverse genetic systems: Rational design of coronavirus live attenuated vaccines with immune sequelae #MMPMID32711735 Ma Z; Li Z; Dong L; Yang T; Xiao S Adv Virus Res 2020[]; 107 (ä): 383-416 PMID32711735show ga Since the end of 2019, the global COVID-19 outbreak has once again made coronaviruses a hot topic. Vaccines are hoped to be an effective way to stop the spread of the virus. However, there are no clinically approved vaccines available for coronavirus infections. Reverse genetics technology can realize the operation of RNA virus genomes at the DNA level and provide new ideas and strategies for the development of new vaccines. In this review, we systematically describe the role of reverse genetics technology in studying the effects of coronavirus proteins on viral virulence and innate immunity, cell and tissue tropism and antiviral drug screening. An efficient reverse genetics platform is useful for obtaining the ideal attenuated strain to prepare an attenuated live vaccine. |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/immunology/*prevention & control[MESH] |Genome, Viral/genetics[MESH] |Humans[MESH] |Pandemics/*prevention & control[MESH] |Pneumonia, Viral/immunology/*prevention & control[MESH] |RNA, Viral/genetics[MESH] |Reverse Genetics/methods[MESH] |SARS-CoV-2[MESH] |Vaccines, Synthetic/*immunology[MESH] |Viral Proteins/*genetics/*immunology[MESH]Reverse genetic systems: Rational design of coronavirus live attenuate(epmc).pdf DeepDyve Pubget Overpricing