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10.1093/infdis/jiaa451

http://scihub22266oqcxt.onion/10.1093/infdis/jiaa451
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32710762!7454707!32710762
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suck abstract from ncbi


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pmid32710762      J+Infect+Dis 2022 ; 226 (2): 278-286
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  • Reliability of Self-Sampling for Accurate Assessment of Respiratory Virus Viral and Immunologic Kinetics #MMPMID32710762
  • Waghmare A; Krantz EM; Baral S; Vasquez E; Loeffelholz T; Chung EL; Pandey U; Kuypers J; Duke ER; Jerome KR; Greninger AL; Reeves DB; Hladik F; Cardozo-Ojeda EF; Boeckh M; Schiffer JT
  • J Infect Dis 2022[Aug]; 226 (2): 278-286 PMID32710762show ga
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic demonstrates the need for accurate and convenient approaches to diagnose and therapeutically monitor respiratory viral infections. We demonstrated that self-sampling with mid-nasal foam swabs is well-tolerated and provides quantitative viral output concordant with flocked swabs. Using longitudinal home-based self-sampling, we demonstrate that nasal cytokine levels correlate and cluster according to immune cell of origin. Periods of stable viral loads are followed by rapid elimination, which could be coupled with cytokine expansion and contraction. Nasal foam swab self-sampling at home provides a precise, mechanistic readout of respiratory virus shedding and local immune responses.
  • |*COVID-19/diagnosis[MESH]
  • |*Viruses[MESH]
  • |Cytokines[MESH]
  • |Humans[MESH]
  • |Kinetics[MESH]
  • |Reproducibility of Results[MESH]


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