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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Commun 2020 ; 11 (1): 3774 Nephropedia Template TP
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Patients with immune-mediated inflammatory diseases receiving cytokine inhibitors have low prevalence of SARS-CoV-2 seroconversion #MMPMID32709909
Simon D; Tascilar K; Kronke G; Kleyer A; Zaiss MM; Heppt F; Meder C; Atreya R; Klenske E; Dietrich P; Abdullah A; Kliem T; Corte G; Morf H; Leppkes M; Kremer AE; Ramming A; Pachowsky M; Schuch F; Ronneberger M; Kleinert S; Maier C; Hueber AJ; Manger K; Manger B; Berking C; Tenbusch M; Uberla K; Sticherling M; Neurath MF; Schett G
Nat Commun 2020[Jul]; 11 (1): 3774 PMID32709909show ga
Immune-mediated inflammatory diseases (IMIDs) of the joints, gut and skin are treated with inhibitors of inflammatory cytokines. These cytokines are involved in the pathogenesis of coronavirus disease 2019 (COVID-19). Investigating anti-SARS-CoV-2 antibody responses in IMIDs we observe a reduced incidence of SARS-CoV-2 seroconversion in IMID patients treated with cytokine inhibitors compared to patients receiving no such inhibitors and two healthy control populations, despite similar social exposure. Hence, cytokine inhibitors seem to at least partially protect from SARS-CoV-2 infection.