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Selenium Deficiency Is Associated with Mortality Risk from COVID-19 #MMPMID32708526
Moghaddam A; Heller RA; Sun Q; Seelig J; Cherkezov A; Seibert L; Hackler J; Seemann P; Diegmann J; Pilz M; Bachmann M; Minich WB; Schomburg L
Nutrients 2020[Jul]; 12 (7): ä PMID32708526show ga
SARS-CoV-2 infections underlie the current coronavirus disease (COVID-19) pandemic and are causative for a high death toll particularly among elderly subjects and those with comorbidities. Selenium (Se) is an essential trace element of high importance for human health and particularly for a well-balanced immune response. The mortality risk from a severe disease like sepsis or polytrauma is inversely related to Se status. We hypothesized that this relation also applies to COVID-19. Serum samples (n = 166) from COVID-19 patients (n = 33) were collected consecutively and analyzed for total Se by X-ray fluorescence and selenoprotein P (SELENOP) by a validated ELISA. Both biomarkers showed the expected strong correlation (r = 0.7758, p < 0.001), pointing to an insufficient Se availability for optimal selenoprotein expression. In comparison with reference data from a European cross-sectional analysis (EPIC, n = 1915), the patients showed a pronounced deficit in total serum Se (mean +/- SD, 50.8 +/- 15.7 vs. 84.4 +/- 23.4 microg/L) and SELENOP (3.0 +/- 1.4 vs. 4.3 +/- 1.0 mg/L) concentrations. A Se status below the 2.5th percentile of the reference population, i.e., [Se] < 45.7 microg/L and [SELENOP] < 2.56 mg/L, was present in 43.4% and 39.2% of COVID samples, respectively. The Se status was significantly higher in samples from surviving COVID patients as compared with non-survivors (Se; 53.3 +/- 16.2 vs. 40.8 +/- 8.1 microg/L, SELENOP; 3.3 +/- 1.3 vs. 2.1 +/- 0.9 mg/L), recovering with time in survivors while remaining low or even declining in non-survivors. We conclude that Se status analysis in COVID patients provides diagnostic information. However, causality remains unknown due to the observational nature of this study. Nevertheless, the findings strengthen the notion of a relevant role of Se for COVID convalescence and support the discussion on adjuvant Se supplementation in severely diseased and Se-deficient patients.
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Nutrients 2020 ; 12 (7): ä
