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10.3390/cancers12071992 http://scihub22266oqcxt.onion/10.3390/cancers12071992 32708264!7409316!32708264     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancers+(Basel) 2020 ; 12 (7): ä Nephropedia Template TP {{tp|p=32708264|t=2020. Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19 |pdf=|usr=}}{{32708264}} gab.com Text Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19 JO: Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=32708264 #FOAvip Advanced age or preexisting comorbidities have been characterized as risk factors for severe coronavirus disease 2019 (COVID-19) cases requiring hospitalization and intensive care. In recent years, clonal hematopoiesis (CH) of indeterminate potential (CHIP) has emerged as a risk factor for chronic inflammatory background and subsequent aging-associated diseases. The purpose of this study was to identify biological factors (particularly leukocyte subtypes and inflammatory markers) associated with a risk of clinical deterioration (i.e., orotracheal intubation (OTI)) and to determine whether CH was likely to influence clinical and biological behavior in patients with severe COVID-19 requiring hospitalization. Here, we describe clinical and biological features, including the screening of CHIP mutants in a well-annotated cohort of 122 hospitalized patients with a laboratory-confirmed diagnosis of COVID-19 (55% requiring OTI). We showed that elevated white blood cell counts, especially neutrophils and high C-reactive protein (CRP) levels at admission, were associated with an increased requirement of OTI. We noticed a high prevalence of CH (25%, 38%, 56%, and 82% of patients aged <60 years, 60-70 years, 70-80 years, and >80 years) compared to a retrospective cohort of patients free of hematological malignancy explored with the same pipelines (10%, 21%, 37%, and 44%). However, the existence of CH did not significantly impact clinical outcome, including OTI or death, and did not correlate with other laboratory findings. Twit Text FOAVip Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19 ????Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=32708264 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32708264 #FOAvip English Wikipedia <ref>{{Cite pmid|32708264}}</ref> Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19 #MMPMID32708264 Duployez N; Demonchy J; Berthon C; Goutay J; Caplan M; Moreau AS; Bignon A; Marceau-Renaut A; Garrigue D; Raczkiewicz I; Geffroy S; Bucci M; Alidjinou K; Demaret J; Labalette M; Brousseau T; Dupont A; Rauch A; Poissy J; Susen S; Preudhomme C; Quesnel B Cancers (Basel) 2020[Jul]; 12 (7): ä PMID32708264show ga Advanced age or preexisting comorbidities have been characterized as risk factors for severe coronavirus disease 2019 (COVID-19) cases requiring hospitalization and intensive care. In recent years, clonal hematopoiesis (CH) of indeterminate potential (CHIP) has emerged as a risk factor for chronic inflammatory background and subsequent aging-associated diseases. The purpose of this study was to identify biological factors (particularly leukocyte subtypes and inflammatory markers) associated with a risk of clinical deterioration (i.e., orotracheal intubation (OTI)) and to determine whether CH was likely to influence clinical and biological behavior in patients with severe COVID-19 requiring hospitalization. Here, we describe clinical and biological features, including the screening of CHIP mutants in a well-annotated cohort of 122 hospitalized patients with a laboratory-confirmed diagnosis of COVID-19 (55% requiring OTI). We showed that elevated white blood cell counts, especially neutrophils and high C-reactive protein (CRP) levels at admission, were associated with an increased requirement of OTI. We noticed a high prevalence of CH (25%, 38%, 56%, and 82% of patients aged <60 years, 60-70 years, 70-80 years, and >80 years) compared to a retrospective cohort of patients free of hematological malignancy explored with the same pipelines (10%, 21%, 37%, and 44%). However, the existence of CH did not significantly impact clinical outcome, including OTI or death, and did not correlate with other laboratory findings. äClinico-Biological Features and Clonal Hematopoiesis in Patients with (epmc).pdf DeepDyve Pubget Overpricing